TY - JOUR JO - Pediatric Endocrinology Diabetes and Metabolism SN - 2081-237X VL - 28 IS - 1 PY - 2022 ID - Boro2022 TI - Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler AB - Cushing’s syndrome is a rare disease in the paediatric age group. Adrenocortical carcinomas (ACC) constitute the most common cause of Cushing’s syndrome between 1 and 5 years of age. Often, adrenocortical carcinomas co-secrete other hormones such as androgens (testosterone), deoxy-corticosterone (DOCA), or 17-hydroxy-progesterone [17(OH)P] in addition to cortisol. This may manifest with symptoms and signs of precocious puberty along with Cushing’s syndrome. It is rare for a benign adrenocortical adenoma to co-secrete androgens and other hormones in addition to cortisol. Differentiation between adenoma and carcinoma is difficult in all aspects: clinical, radiological, and histopathological. Here, we describe the case of a 2.5-year-old male child who presented with Cushing’s syndrome and virilization. Although we suspected ACC clinically, the radiological and histopathological findings were suggestive of benign adrenocortical adenoma. Our case represents the diagnostic challenge that exists in paediatric adrenocortical tumours. AU - Boro, Hiya AU - Kubihal, Suraj AU - Dutta, Rimlee AU - Kubihal, Vijay AU - Alam, Sarah AU - Tandon, Nikhil SP - 81 EP - 87 DA - 2022 DO - 10.5114/pedm.2021.109122 UR - http://dx.doi.org/10.5114/pedm.2021.109122 ER -