TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 46 IS - 3 PY - 2021 ID - Bajoriuniene2021 TI - DiHS/DRESS syndrome induced by second-line treatment for tuberculosis and Epstein-Barr virus AB - Drug-induced hypersensitivity syndrome (DiHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced reaction characterized by various symptoms: skin rash, fever, lymph node enlargement and internal organ involvement, which starts within 2 weeks to 3 months after drug initiation. It is challenging to diagnose this syndrome due to the variety of cutaneous and visceral symptoms. Different mechanisms have been implicated in its development, including genetic susceptibility associated with human leucocyte antigen (HLA) loci, detoxification defects leading to reactive metabolite formation and subsequent immunological reactions, slow acetylation, and reactivation of human herpes, including Epstein-Barr virus and human herpes virus (HHV)-6 and HHV-7. The most frequently reported causes of DiHS/DRESS are antiepileptic agents, allopurinol and sulfonamides. We report a case of DiHS/DRESS induced by second-line treatment for tuberculosis, prothionamide and para-aminosalicylic acid, and Epstein-Barr virus re-infection. Patch testing, which was performed in this case, is not fully standardized, but it can be helpful and a safe way to evaluate and diagnose DiHS/DRESS. AU - Bajoriuniene, Ieva AU - Musteikiene, Greta AU - Ramonaite, Agne AU - Sitkauskiene, Brigita SP - 401 EP - 404 DA - 2021 DO - 10.5114/ceji.2021.109670 UR - http://dx.doi.org/10.5114/ceji.2021.109670 ER -