TY - JOUR JO - Pediatric Endocrinology Diabetes and Metabolism SN - 2081-237X VL - 28 IS - 1 PY - 2022 ID - Dekker2022 TI - Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance AB - Many C-peptide assays are commercially available for research and routine use. However, not all assays yield consistent results, especially in the low concentration ranges. We searched the literature describing C-peptide measurements to assess which assays are mainly used in the diabetes research field and if they are specified. Percentages of publications on C-peptide measurements in type 1 diabetes (T1D), type 2 diabetes (T2D) and other forms of diabetes were 32%, 54% and 14%, respectively. In only 54% of the publications the used assay was specified. Information on detection limit, measurement range and variation was provided in 12%, 2% and 11% of publications, respectively. In 22% of all publications no C-peptides concentrations were mentioned. This may be a problem especially for T1D research, where measuring very low levels of C-peptide is becoming increasingly important and concordance between assays is low. AU - Dekker, Pim AU - de Vries, Martine AU - Aanstoot, Henk-Jan AU - Groen, Joost SP - 101 EP - 103 DA - 2022 DO - 10.5114/pedm.2022.113741 UR - http://dx.doi.org/10.5114/pedm.2022.113741 ER -