TY - JOUR JO - Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii SN - 1642-395X VL - 39 IS - 6 PY - 2022 ID - Nowogrodzka2022 TI - Emerging biomarker in carcinogenesis. Focus on Nestin AB - Nestin is a protein belonging to class VI intermediate filaments, which is involved in organogenesis, cellular metabolism and cytoskeletal organisation. Originally found to be expressed in neuroepithelial stem cells, nestin is also expressed in other tissues. It plays an important role in the carcinogenesis and angiogenesis. Its increased expression in melanoma is associated with an aggressive course of the disease and poor prognosis. Research findings for non-melanocytic skin neoplasms are inconclusive. The aim of this paper was to systematize knowledge on the role of nestin in cancerogenesis. The authors focused in particular on the expression of nestin in skin malignancies, as well as on the potential role of nestin in the pathogenesis, prognosis and treatment of cutaneous neoplasms. AU - Nowogrodzka, Katarzyna AU - Jankowska-Konsur, Alina SP - 1001 EP - 1007 DA - 2022 DO - 10.5114/ada.2022.122599 UR - http://dx.doi.org/10.5114/ada.2022.122599 ER -