TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 29 IS - 3 PY - 2004 ID - Szymańska2004 TI - Experimental immunologyImmunophenotypes of spontaneous lymphomas in inbred mice – a contribution to mouse models of human lymphoid neoplasms AB - The Haematopathology Subcommittee of the Mouse Models of Human Cancer Consortium has proposed that mouse lymphoid neoplasms be used as models of human lymphomas. As a contribution to the proposed classification of mouse lymphomas according to the WHO classification of human lymphoid neoplasms, we evaluated the immunophenotypes of spontaneously developed lymphomas in group of 99 AKR/W mice, 108 C57BL/6W mice, 51 C57BL/10W mice, 46 BALB/cW and 57 129/SvW mice. Two immunohistochemical methods, ABComplex and MOM ® , and flow cytometry with 13 monoclonal antibodies were used. In AKR/W mice, 99% of spontaneous lymphomas were Tcell derived, while this immunophenotype accounted for only 40% of lymphoid neoplasms in BALB/cW mice, 35% in C57BL/6W, 6% in C57BL/10W and 13% in 129/SvW mice. The T-cell derived lymphomas appeared earlier in AKR/W mice (median age 271 days) than in the other strains (median age 628-866 days) (p<0.0001). The incidence of B-cell lymphomas was highest in C57BL/10W mice (94%), 88% in 129/SvW mice, 65% in C57BL/6W mice, 60% in BALB/cW mice and only 0.01% in AKR/W mice. B-cell lymphomas developed only in aging mice (median age 787 days). The T-cell lymphomas had five different immunophenotypes, while the B-cell lymphomas had only one immunophenotype characteristic for mature B-cells. The lymphomas developed in these common mouse strains could be useful as models for human lymphomas. AU - Szymańska, Hanna AU - Piskorowska, Joanna AU - Krysiak, Elżbieta AU - Skurzak, Henryk Marian AU - Kraszewska, Ewa AU - Czarnomska, Alina SP - 3 EP - 4 DA - 2004 UR - https://www.termedia.pl/Experimental-immunology-Immunophenotypes-of-spontaneous-lymphomas-in-inbred-mice-8211-a-contribution-to-mouse-models-of-human-lymphoid-neoplasms,10,5470,1,1.html ER -