TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 29 IS - 3 PY - 2004 ID - Łącka2004 TI - Review paper Current views on the etiopathogenesis AB - Thyroid associated ophthalmopathy (TAO) is an autoimmune disorder often coexisting with Graves’ disease, where clinical symptoms result from the inflammatory reactions occurring in retroorbital tissue. The mechanisms responsible for disease evolution have not been precisely recognized. Infectious, environmental, immune and genetic factors are likely to take part in the development of the disease. Recently, intensive research of cytokines influence on thyroid cells and retroorbital tissue have been undertaken. The cytokines group which takes part in TAO pathogenesis is very large, but the role of each individual cytokine is not yet fully known. The gene polymorphisms of these cytokines are also being investigated. The results of the studies obtained so far are not explicit. However, it can be expected that in the near future a cytokines genes polymorphism estimation in patients with thyroid associated ophthalmopathy and Graves’ disease will be a helpful means to choose the treatment method and to establish the prognosis. AU - Łącka, Katarzyna AU - Szarzyńska, Joanna AU - Łącki, Jan K. SP - 3 EP - 4 DA - 2004 UR - https://www.termedia.pl/Review-paper-Current-views-on-the-etiopathogenesis,10,5473,1,1.html ER -