TY - JOUR JO - Menopause Review/PrzeglÄ…d Menopauzalny SN - 1643-8876 VL - 6 IS - 5 PY - 2007 ID - Szymanowski2007 TI - Evaluation of the effectiveness of RESAN vaccine in the prophylaxis and treatment of endometriosis – an experimental study in an animal model. Part I AB - Endometriosis is a serious social problem. There is no fully effective form of treatment of endometriosis. Immunomodulation might be a chance to improve the results. Objectives: The aim of our study was to evaluate the effectiveness of the RESAN vaccine in the prevention and treatment of endometriosis in an experimental animal study. Materials and methods: A group of 58 sexually mature female rats was divided into three smaller groups. During the first step of the experiment RESAN vaccine was injected in group I of rats (n=24). Three months later during the 2nd step of the examination endometriosis was implanted in groups I and II (n=24). Group III (n=10) was a control group where sham operations were performed. Three months later endometrial implants were removed and examined histologically. Meanwhile RESAN vaccine was injected as a treatment in group II (step 3). Three months later an excision of the suspected foci was performed with histological examination of the tissue samples (step 4). Results: During step 3, the endometriosis was histologically diagnosed in 1 rat from group I and in 16 from group II. Adhesions near the endometrial implant were found in 3 and 14 rats from groups I and II, respectively. There were no endometriotic foci in all groups during the 4th step of the examination. Conclusions: 1. RESAN vaccine is an effective form of endometriosis prevention in a rat model. 2. Immunotherapy connected with surgical treatment is an effective form of treatment in an animal model of endometriosis. AU - Szymanowski, Krzysztof AU - Chmaj-Wierzchowska, Karolina AU - Niepsuj, Joanna AU - Yanchanka, Andrey AU - Florek, Ewa AU - Barlik, Magdalena AU - Opala, Tomasz SP - 283 EP - 288 DA - 2007 UR - https://www.termedia.pl/Evaluation-of-the-effectiveness-of-RESAN-vaccine-in-the-prophylaxis-and-treatment-of-endometriosis-8211-an-experimental-study-in-an-animal-model-Part-I,4,9168,1,1.html ER -