Targeted therapy Part I. Signalling by tyrosine kinase receptors

Beata Wiczyńska; Janusz Rolski

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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vol. 11

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abstract:

Targeted therapy Part I. Signalling by tyrosine kinase receptors

Beata Wiczyńska

,

Janusz Rolski

Współczesna Onkologia (2007) vol. 11; 7 (331–336)

Online publish date: 2007/10/02

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Cell signalling is tightly controlled for normal cell function. The signal transduction system comprises ligands (growth factors, cytokines, hormones), transmembrane receptors and cytoplasmic secondary messengers. The crucial effectors in signalling cascades include the Ras-Raf-MAP pathway, lipid kinase phosphoinositide-3-kinase (PI3K) pathway and protein kinase C pathway. Dysregulation of the three major signalling pathways can lead to the malignant phenotype of uncontrolled proliferation, metastasis, angiogenesis and inhibition of apoptosis.

keywords:

Targeted therapy Part I. Signalling by tyrosine kinase receptors

Beata Wiczyńska , Janusz Rolski

signal transduction pathways, receptor tyrosine kinases, non-receptor tyrosine kinases, signaling molecules (ligands)

Beata Wiczyńska

,

Janusz Rolski