eISSN: 2081-2833
ISSN: 2081-0016
Medycyna Paliatywna/Palliative Medicine
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1/2011
vol. 3
 
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abstract:
Review paper

Drug interactions of opioid analgesics – weak opioids

Aleksandra Kotlińska-Lemieszek

Medycyna Paliatywna 2011; 1: 11–18
Online publish date: 2011/04/07
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Drugs used in a patient create a net of complex relations. These agents modify their effect in multiple mechanisms, including acting at the same receptor, enzyme or effector, as well as affecting all phases of pharmacokinetics, from absorption to elimination. The knowledge on this issue is still fragmentary, based on experimental in vitro studies, surveys on volunteers, very few clinical studies and single case reports. The article comprises the review of the literature on interactions of the second step of WHO analgesic ladder opioids.
keywords:

weak opioids, drug interactions, serotonine syndrome, seizures, respiratory depression

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