Połubok J, Gonera A, Jasielska O, et al. Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood. Pediatric Endocrinology Diabetes and Metabolism. 2015;21(2).
APA
Połubok, J., Gonera, A., Jasielska, O., Sęga-Pondel, D., Galant, K., & Kazanowska, B. et al. (2015). Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood. Pediatric Endocrinology Diabetes and Metabolism, 21(2).
Chicago
Połubok, Joanna, Aleksandra Gonera, Olimpia Jasielska, Dorota Sęga-Pondel, Karolina Galant, Bernarda Kazanowska, and Ewa Barg. 2015. "Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood". Pediatric Endocrinology Diabetes and Metabolism 21 (2).
Harvard
Połubok, J., Gonera, A., Jasielska, O., Sęga-Pondel, D., Galant, K., Kazanowska, B., and Barg, E. (2015). Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood. Pediatric Endocrinology Diabetes and Metabolism, 21(2).
MLA
Połubok, Joanna et al. "Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood." Pediatric Endocrinology Diabetes and Metabolism, vol. 21, no. 2, 2015.
Vancouver
Połubok J, Gonera A, Jasielska O, Sęga-Pondel D, Galant K, Kazanowska B et al. Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood. Pediatric Endocrinology Diabetes and Metabolism. 2015;21(2).
Introduction . Continuously improving treatment of childhood cancers leads to the better survival rate, but at the same time causes long-term consequences. The aim of our study was to evaluate the incidence of selected endocrine disorders after anticancer treatment of solid tumors. Materials and methods . The study group consisted of 74 patients (48 boys), aged 3.25-27 years (mean 13.24± 6.21), at least one year after anticancer therapy of solid tumours. Thyroid function, concentration of: sex hormones, lipids (cholesterol/LDL/TG, HDL), IGF-1 (ng/ml), PTH (pg/ml) were assessed. BMD (Z-score) were evaluated. Following anthropometric parameters were examined: height SDS, body mass SDS and BMI SDS. Results . Endocrinological abnormalities were found in 66 (89.19%) of patients. Most of the patients (67.57%) had one or two disturbances. Most common abnormalities were dyslipidaemia found in 39 (58.21%) patients and overweight/obesity in 25 (33.78%). Other abnormalities were as follows: disturbance in sex hormones in 14 (27.45%) patients, abnormal PTH in 13 (19.4%), abnormal IGF-1 in 9 (14.75%), short stature in 9 (12.16%) underweight in 8 (11.11%), hypothyroidism in 7 (9.72%), low BMD 6 (8.69%) and hyperthyroidism in 2 (2.78%). Conclusions . Patients after anticancer treatment during childhood are significantly exposed to endocrine disorders. These patients require detailed follow-up examinations to detect abnormalities and to implement the appropriate treatment. It should be noted that there is frequent coexistence of multiple disorders to one patient.
Keywords
late effects, anticancer treatment, lipids, BDM, IGF1