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Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity

" /> Pełny tekst: Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity, Mohammad Ali Gharaat - Postępy w Kardiologii Interwencyjnej 1/2026
Postępy w Kardiologii Interwencyjnej

Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity

Mohammad Ali Gharaat 1
,
Mohsen Sheykhlouvand 1
,
Hamid Reza Choobdari 1
,
Katsuhiko Suzuzki 1
,
Hamid Arazi 1

  1. Department of Physical Education, Farhangian University, Tehran, Iran

DOI: https://doi.org/10.5114/aic.2026.161944
Data publikacji online: 2026/05/27
Plik artykułu
Exercise-induced cardiac.pdf
  1. Li J, Gao E, Vite A, et al. Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ Res 2015; 116: 70-9.
  2. Melo SFS, da Silva Júnior ND, Barauna VG, Oliveira EM. Cardiovascular adaptations induced by resistance training in animal models. Int J Med Sci 2018; 15: 403-10.
  3. Gharaat MA, Ramezani A. Effect of two high intensity interval trainings on performance and rheological characteristics of elite male rowers. J Pract Stud Biosci Sport 2018; 6: 135-44.
  4. Martin TG, Juarros MA, Leinwand LA. Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential. Nat Rev Cardiol 2023; 20: 347-63.
  5. Maessen MF, Eijsvogels TM, Stevens G, et al. Benefits of lifelong exercise training on left ventricular function after myocardial infarction. Eur J Prev Cardiol 2017; 24: 1856-66.
  6. Forsa MI, Bjerring AW, Haugaa KH, et al. Young athlete’s growing heart: sex differences in cardiac adaptation to exercise training during adolescence. Open Heart 2023; 10: e002155.
  7. Sheykhlouvand M, Gharaat MA. Optimal homeostatic stress to maximize the homogeneity of adaptations to interval interventions in soccer players. Front Physiol 2024; 15: 1377552.
  8. Gharaat MA, Kashef M, Jameie B, Rajabi H. Effect of endurance and high intensity interval swimming training on cardiac hypertrophy of male rats. J Shahid Sadoughi Uni Med Sci 2018; 26: 306-18.
  9. Gharaat MA, Karami S, Sheykhlouvand M, Rajabi H. Regulation of angiogenic genes and endothelial progenitor cells following resistance training in elderly men. Sport Sci Health 2025. https://doi.org/10.1007/s11332-024-01322-5
  10. Sheykhlouvand M, Arazi H, Astorino TA, Suzuki K. Effects of a new form of resistance-type high-intensity interval training on cardiac structure, hemodynamics, and physiological and performance adaptations in well-trained kayak sprint athletes. Front Physiol 2022; 13: 850768.
  11. Vujic A, Lerchenmüller C, Wu TD, et al. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun 2018; 9: 1659.
  12. Bruss ZS, Raja A. Physiology, Stroke Volume. In: StatPearls. StatPearls Publishing; 2022.
  13. Mirzaaghajani A, Alikhani H, Hojjati Z, Gharaat M. Comparison of the effects of continuous and high intensity interval training on aerobic performance in elite male rowers. J Pract Stud Biosci Sport 2016; 4: 23-32.
  14. Galanti G, Stefani L, Mascherini G, et al. Left ventricular remodeling and the athlete’s heart, irrespective of quality load training. Cardiovasc Ultrasound 2016; 14: 46.
  15. Gharaat MA, Mehri Alvar Y. Effect of resistance training modalities on angiogenic indices in sedentary male students. Tehran Uni Med Sci J 2023; 81: 441-9.
  16. Haykowsky MJ, Dressendorfer R, Taylor D, et al. Resistance training and cardiac hypertrophy. Sports Med 2002; 32: 837-49.
  17. Fereshtian S, Sheykhlouvand M, Forbes S, Gharaat M. Physiological and performance responses to high-intensity interval training in female inline speed skaters. Apunts Med de l’Esport 2017; 52: 131-8.
  18. Fernandes T, Hashimoto NY, Magalhães FC, et al. Aerobic exercise training–induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). J Hypertens 2011; 58: 182-9.
  19. Gharaat MA, Kashef M, Jameie B, Rajabi H. Effect of endurance and high intensity interval swimming training on cardiac structure and Hand2 expression of rats. J Shahid Sadoughi Uni Med Sci 2017; 25: 748-58.
  20. Brito ADF, Soares YM, Silva AS. Concurrent training or combined training? Rev Bras Med Esport 2019; 25: 105-6.
  21. McMullen JR, Shioi T, Huang WY, et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110a) pathway. J Biol Chem 2004; 279: 4782-93.
  22. Sanz-de la Garza M, Rubies C, Batlle M, et al. Severity of structural and functional right ventricular remodeling depends on training load in an experimental model of endurance exercise. Am J Physiol Heart Circ Physiol 2017; 313: H459-68.
  23. Xiang K, Qin Z, Zhang H, Liu X. Energy metabolism in exercise-induced physiologic cardiac hypertrophy. Front Pharmacol 2020; 11: 1133.
  24. Barauna VG, Rosa KT, Irigoyen MC, De Oliveira EM. Effects of resistance training on ventricular function and hypertrophy in a rat model. Clin Med Res 2007; 5: 114-20.
  25. Fernandes T, Soci U, Oliveira E. Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants. Braz J Med Biol Res 2011; 44: 836-47.
  26. Wang H, Xie Y, Guan L, et al. Targets identified from exercised heart: killing multiple birds with one stone. NPJ Regen Med 2021; 6: 23.
  27. de Souza EO, Tricoli VS, Aoki MS, et al. Effects of concurrent strength and endurance training on genes related to myostatin signaling pathway and muscle fiber responses. J Strength Cond Res 2024; 28: 3215-23.
  28. Bass-Stringer S, Tai CM, McMullen JR. IGF1–PI3K-induced physiological cardiac hypertrophy: implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity. J Sport Health Sci 2021; 10: 637-47.
  29. Weeks KL, Tham YK, Yildiz SG, et al. FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol 2021; 320: H1470-85.
  30. Morkin E. Regulation of myosin heavy chain genes in the heart. J Circ 1993; 87: 1451-60.
  31. Thompson JT, Rackley MS, O’Brien T. Upregulation of the cardiac homeobox gene Nkx2–5 (CSX) in feline right ventricular pressure overload. Am J Physiol 1998; 274: H1569-73.
  32. Schwartz K, de la Bastie D, Bouveret P, et al. Alpha-skeletal muscle actin mRNA’s accumulate in hypertrophied adult rat hearts. Circ Res 1986; 59: 551-5.
  33. Hirzel HO, Tuchschmid CR, Schneider J, et al. Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy. Circ Res 1985; 57: 729-40.
  34. Utomi V, Oxborough D, Ashley E, et al. Predominance of normal left ventricular geometry in the male ‘athlete’s heart’. Heart 2014; 100: 1264-71.
  35. Medeiros C, Frederico MJ, da Luz G, et al. Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. J Cell Physiol 2011; 226: 666-74.
  36. Tóth ME, Sárközy M, Szűcs G, et al. Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome. Biol Sex Differ 2022; 13: 5.
  37. Barauna VG, Magalhaes FC, Krieger JE, Oliveira EM. AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats. Am J Physiol Regul Integr Comp Physiol 2008; 295: R381-7.
  38. Barauna VG, Junior ML, Costa Rosa LF, et al. Cardiovascular adaptations in rats submitted to a resistance-training model. Clin Exp Pharmacol Physiol 2005; 32: 249-54.
  39. Naderi N, Hemmatinafar M, Gaeini AA, et al. High-intensity interval training increase GATA4, CITED4 and c-Kit and decreases C/EBPb in rats after myocardial infarction. Life Sci 2019; 221: 319-26.
  40. Izumiya Y, Shiojima I, Sato K, et al. Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. J Hypertens 2006; 47: 887-93.
  41. Mendes-Ferreira P, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Therapeutic potential of neuregulin-1 in cardiovascular disease. Drug Discov Today 2013; 18: 836-42.
  42. Weeks KL, Bernardo BC, Ooi JY, et al. The IGF1-PI3K-Akt signaling pathway in mediating exercise-induced cardiac hypertrophy and protection. Adv Exp Med Biol 2017; 1000: 187-210.
  43. Allard JB, Duan C. IGF-binding proteins: why do they exist and why are there so many? Front Endocrinol 2018; 9: 117.
  44. Kemi OJ, Loennechen JP, Wisløff U, Ellingsen Ø. Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol 2002; 93: 1301-9.
  45. Macvanin M, Gluvic Z, Radovanovic J, et al. New insights on the cardiovascular effects of IGF-1. Front Endocrinol 2023; 14: 1142644.
  46. Gusscott S, Jenkins CE, Lam SH, et al. IGF1R derived PI3K/AKT signaling maintains growth in a subset of human T-cell acute lymphoblastic leukemias. PLoS One 2016; 11: e0161158.
  47. Obradovic M, Stanimirovic J, Panic A, et al. Regulation of Na+/K+-ATPase by estradiol and IGF-1 in cardio-metabolic diseases. Curr Pharm Des 2017; 23: 1551-61.
  48. Tao L, Bei Y, Zhang H, et al. Exercise for the heart: signaling pathways. Oncotarget 2015; 6: 20773.
  49. Lay AC, Hale LJ, Stowell-Connolly H, et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates b1-integrin/FAK signalling in human podocytes. Diabetologia 2021; 64: 1690-702.
  50. Cheng W, Li B, Kajstura J, et al. Stretch-induced programmed myocyte cell death. J Clin Invest 1995; 96: 2247-59.
  51. Gharaat MA, Choobdari HR, Khajavi N, Shafabakhsh SR. Effect of swimming training on cardiac morphological factors, apelin and insulin like growth factor-1 in male wistar rats. J Shahid Sadoughi Univ 2023; 31: 6944-54.
  52. Gharaat MA. Effect of aerobic and Interval training on Insulin-like growth factor-1, GATA4 gene and cardiac structure. J Arak Univ Med Sci 2024; 27: 186-93.
  53. Kim J, Wende AR, Sena S, et al. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol 2008; 22: 2531-43.
  54. Neri Serneri GG, Boddi M, Modesti PA, et al. Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circ Res 2001; 89: 977-82.
  55. Zebrowska A, Zyła D, Kania D, Langfort J. Anaerobic and aerobic performance of elite female and male snowboarders. J Hum Kinet 2012; 34: 81-8.
  56. Ma Z, Qi J, Meng S, et al. Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway. Eur J Appl Physiol 2013; 113: 2473-86.
  57. Palabiyik O, Tastekin E, Doganlar ZB, et al. Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133. Biomed Rep 2019; 10: 97-106.
  58. Frey N, Katus HA, Olson EN, Hill J. Hypertrophy of the heart: a new therapeutic target? J Clin Invest 2004; 109: 1580-9.
  59. Salazar NC, Chen J, Rockman HA. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta 2007; 1768: 1006-18.
  60. Reiter E, Ahn S, Shukla AK, Lefkowitz RJ. Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 2012; 52: 179-97.
  61. Peng WW, Hong L, Liu GY, et al. Prehypertension exercise training attenuates hypertension and cardiac hypertrophy accompanied by temporal changes in the levels of angiotensin II and angiotensin (1-7). Hypertens Res 2019; 42: 1745-56.
  62. Gallo S, Vitacolonna A, Bonzano A, et al. ERK: a key player in the pathophysiology of cardiac hypertrophy. Int J Mol Sci 2019; 20: 2164.
  63. Thattaliyath BD, Firulli BA, Firulli AB. The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol 2002; 34: 1335-44.
  64. Jin H, Wyss JM, Yang R, Schwall RJ. The therapeutic potential of hepatocyte growth factor for myocardial infarction and heart failure. Curr Pharm Des 2004; 10: 2525-33.
  65. Xiao J, Xu T, Li J, et al. Exercise-induced physiological hypertrophy initiates activation of cardiac progenitor cells. Int J Clin Exp Pathol 2014; 7: 663-9.
  66. Chen AL, Ou CW, He ZC, et al. Effect of hepatocyte growth factor and angiotensin II on rat cardiomyocyte hypertrophy. Braz J Med Biol Res 2012; 45: 1150-6.
  67. Yasuda S, Goto Y, Takaki H, et al. Exercise-induced hepatocyte growth factor production in patients after acute myocardial infarction: its relationship to exercise capacity and brain natriuretic peptide levels. Circ J 2004; 68: 304-7.
  68. Wahl P, Jansen F, Achtzehn S, et al. Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors. PLoS One 2014; 9: e96024.
  69. Kitta K, Day RM, Kim Y, et al. Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem 2003; 278: 4705-12.
  70. Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004; 15: 197-204.
  71. Kalra K, Eberhard J, Farbehi N, et al. Role of PDGF-A/B ligands in cardiac repair after myocardial infarction. Front Cell Dev Biol 2021; 9: 669188.
  72. Nyström HC, Lindblom P, Wickman A, et al. Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries. Cardiovasc Res 2006; 71: 557-65.
  73. Wang X, Yi X, Tang D. Regular aerobic exercise activates PDGF-BB/PDGFR-b signaling and modulates the inflammatory-anti-inflammatory balance in diet-induced obese mice. Obes Res Clin Pract 2021; 15: 387-94.
  74. Rupert CE, Coulombe KL. The roles of neuregulin-1 in cardiac development, homeostasis, and disease. Biomark Insights 2015; 10 (Suppl 1): 1-9.
  75. Ryall KA, Bezzerides VJ, Rosenzweig A, Saucerman JJ. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. J Mol Cell Cardiol 2014; 72: 74-84.
  76. Zurek M, Johansson E, Palmer M, et al. Neuregulin-1 induces cardiac hypertrophy and impairs cardiac performance in post-myocardial infarction rats. J Circ 2020; 142: 1308-11.
  77. Geissler A, Ryzhov S, Sawyer DB. Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease. Clin Sci (Lond) 2020; 134: 2623-43.
  78. Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009; 138: 257-70.
  79. Oliveira RS, Ferreira JC, Gomes ER, et al. Cardiac anti-remodeling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signaling pathway in heart failure mice. J Physiol 2009; 587: 3899-910.
  80. Rivas DA, Peng F, Benard T, et al. miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition. Am J Physiol Cell Physiol 2021; 321: C977-91.
  81. Diedrichs H, Chi M, Boelck B, et al. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Eur J Heart Fail 2004; 6: 3-9.
  82. Molkentin JD, Lu JR, Antos CL, et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. J Cell Biol 1998; 93: 215-28.
  83. Konstandin MH, Völkers M, Collins B, et al. Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic Res Cardiol 2013; 108: 375.
  84. Eto Y, Yonekura K, Sonoda M, et al. Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. J Clin Invest 2000; 101: 2134-7.
  85. Bourajjaj M, Armand AS, da Costa Martins PA, et al. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem 2008; 283: 22295-303.
  86. Bezzerides VJ, Platt C, Lerchenmüller C, et al. CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI Insight 2016; 1: e85904.
  87. Boström P, Mann N, Wu J, et al. C/EBPb controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 2010; 143: 1072-83.
  88. DeBosch B, Treskov I, Lupu TS, et al. Akt1 is required for physiological cardiac growth. J Clin Invest 2006; 113: 2097-104.
  89. Oka T, Maillet M, Watt AJ, et al. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res 2006; 98: 837-45.
  90. Broderick TL, Parrott CR, Wang D, et al. Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse. Pathophysiology 2012; 19: 193-203.
  91. Harvey RP, Lai D, Elliott D, et al. Homeodomain factor Nkx2-5 in heart development and disease. Cold Spring Harb Symp Quant Biol 2002; 67: 107-14.
  92. Liu X, Xiao J, Zhu H, et al. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab 2015; 21: 584-95.
  93. Li M, Zhang L, Liu X, et al. Inhibition of Rho/ROCK signaling pathway participates in the cardiac protection of exercise training in spontaneously hypertensive rats. Sci Rep 2022; 12: 17903.
  94. Schüttler D, Clauss S, Weckbach LT, Brunner S. Molecular mechanisms of cardiac remodeling and regeneration in physical exercise. J Cells 2019; 8: 1128.
  95. Fujita A, Takahashi-Yanaga F, Morimoto S, et al. 2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation. Hypertens Res 2017; 40: 130-9.
  96. Su M, Chen Z, Wang C, et al. Cardiac-specific overexpression of miR-222 induces heart failure and inhibits autophagy in mice. Cell Physiol Biochem 2016; 39: 1503-11.
  97. Minerath RA, Hall DD, Grueter CE. Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure. Heart Fail Rev 2019; 24: 725-41.
  98. MacNeil LG, Melov S, Hubbard AE, et al. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS One 2010; 5: e10695.
  99. Fernandes T, Baraúna VG, Negrão CE, et al. Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs. Am J Physiol Heart Circ Physiol 2015; 309: H543-52.
  100. Laine S, Högel H, Ishizu T, et al. Effects of different exercise training protocols on gene expression of Rac1 and PAK1 in healthy rat fast- and slow-type muscles. Front Physiol 2020; 11: 584661.
  101. Bo B, Zhou Y, Zheng Q, et al. The molecular mechanisms associated with aerobic exercise-induced cardiac regeneration. Biomolecules 2020; 11: 19.
  102. Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther 2010; 128: 191-227.
  103. Firulli AB, McFadden DG, Lin Q, et al. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet 1998; 18: 266-70.
  104. Moc C, Taylor AE, Chesini GP, et al. Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy. Cardiovasc Res 2015; 105: 160-70.
  105. Gharaat MA, Kashef M, Jameie B, Rajabi H. Regulation of PI3K and Hand2 gene on physiological hypertrophy of heart following high-intensity interval and endurance training. J Res Med Sci 2019; 24: 32.
  106. Dai YS, Cserjesi P, Markham BE, Molkentin JD. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. J Biol Chem 2002; 277: 24390-8.
  107. Laurent F, Girdziusaite A, Gamart J, et al. HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development. Cell Rep 2017; 19: 1602-13.
  108. Fathi M, Gharakhanlou R. The effect of endurance activity on left ventricle Hand2 gene expression in Wistar male rat. J Sport Physiol 2015; 7: 57-68.
  109. Zargani M, Hatami Nasab Z, Feizolahi F, Arabzadeh E. Swimming exercise with L-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats. Biogerontology 2022; 23: 473-84.
  110. Zhou Q, Xiao J. P5395 exercise-induced miR-17-3p prevents pathological myocardial dysfunction. Eur Heart J 2019; 40: ehz746.0355.
  111. Tanaka M, Chen Z, Bartunkova S, et al. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 1999; 126: 1269-80.
  112. Serpooshan V, Liu YH, Buikema JW, et al. Nkx2.5+ cardiomyoblasts contribute to cardiomyogenesis in the neonatal heart. Sci Rep 2017; 7: 12590.
  113. Bonaldo P, Sandri M. Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech 2013; 6: 25-39.
  114. Baskin KK, Taegtmeyer H. Taking pressure off the heart: the ins and outs of atrophic remodelling. Cardiovasc Res 2011; 90: 243-50.
  115. Razeghi P, Sharma S, Ying J, et al. Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation. Circulation 2003; 108: 2536-41.
  116. Cosper PF, Leinwand LA. Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res 2011; 71: 1710-20.
  117. Pelliccia A, Maron BJ, de Luca R, et al. Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation 2002; 105: 944-9.
  118. Hill JA, Olson EN. Cardiac plasticity. N Engl J Med 2008; 358: 1370-80.
  119. Zhao J, Brault JJ, Schild A, et al. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metabolism 2007; 6: 472-83.
  120. Ni YG, Berenji K, Wang N, et al. FOXO transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation 2006; 114: 1159-68.
  121. Schips TG, Wietelmann A, Hohn K, et al. FOXO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Cardiovasc Res 2011; 91: 587-97.
  122. Razeghi P, Volpini KC, Wang ME, et al. Mechanical unloading of the heart activates the calpain system. J Mol Cell Cardiol 2007; 42: 449-52.
  123. Seok HY, Chen J, Kataoka M, et al. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res 2014; 114: 1585-95.
  124. Wang J, Yang X. The function of miRNA in cardiac hypertrophy. Cell Mol Life Sci 2012; 69: 3561-70.
  125. Wehbe N, Nasser SA, Pintus G, et al. MicroRNAs in cardiac hypertrophy. Int J Mol Sci 2019; 20: 4714.
  126. Cheng Y, Ji R, Yue J, et al. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 2007; 170: 1831-40.
  127. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007; 13: 613-8.
  128. Soci UP, Fernandes T, Hashimoto NY, et al. MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats. Physiol Genomics 2011; 43: 665-73.
  129. Pope CA 3rd, Burnett RT, Thurston GD, et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. J Circ 2004; 109: 71-7.
  130. Shi J, Bei Y, Kong X, et al. miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury. Theranostics 2017; 7: 664-76.
  131. Gharaat MA, Choobdari HR, Sheykhlouvand M. Cardioprotective effects of aerobic training in diabetic rats: reducing cardiac apoptotic indices and oxidative stress for a healthier heart. ARYA Atheroscler 2024; 20: 50-60.
  132. Tabrizi A, Soori R, Choobineh S, Gholipour M. Role of endurance training in preventing pathological hypertrophy via large tumor suppressor (LATS) changes. Iran Heart J 2019; 20: 52-9.
  133. Da Silva ND Jr, Fernandes T, Soci UP, et al. Swimming training in rats increases cardiac microRNA-126 expression and angiogenesis. Med Sci Sports Exerc 2012; 44: 1453-62.
  134. Xiong Y, Wang J, Huang S, Cao Y. Investigating the effect of exercise on the expression of genes related to cardiac physiological hypertrophy. Cell Mol Biol (Noisy-le-Grand) 2023; 69: 63-9.
  135. Samadi M, Nazem F, Gharaat MA. Designing the simulation training of taekwondo competition according to heart rate, blood lactate and rating of perceived exertion. Med Dello Sport 2014; 67: 581-92.
  136. Meyler SJR, Swinton PA, Bottoms L, et al. Changes in cardiorespiratory fitness following exercise training prescribed relative to traditional intensity anchors and physiological thresholds: a systematic review with meta-analysis of individual participant data. Sports Med 2025; 55: 301-23.
  137. Hansen D, Junior GC, Milani JGPO, et al. Advancing aerobic exercise training intensity prescription in health and disease beyond standard recommendations: a call to action. Sports Med 2025; 55: 2111-35.
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