A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?

Mikołaj Łanocha; Aleksandra Spyra; Zuzanna Pawlus; Bartosz Miziołek; Beata Bergler-Czop

doi:10.5114/dr.2025.152176

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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1/2025
vol. 112

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abstract:

Case report

A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?

Mikołaj Łanocha

¹

,

Aleksandra Spyra

²

,

Zuzanna Pawlus

²

,

Bartosz Miziołek

¹

,

Beata Bergler-Czop

¹

Department of Dermatology, Medical University of Silesia, Katowice, Poland
Department of Dermatology; Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland

Dermatol Rev/Przegl Dermatol 2025, 112, 47-50

DOI: https://doi.org/10.5114/dr.2025.152176

Online publish date: 2025/05/15

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AMA

Łanocha M, Spyra A, Pawlus Z, Miziołek B, Bergler-Czop B. A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?. Dermatology Review/Przegląd Dermatologiczny. 2025;112(1):47-50. doi:10.5114/dr.2025.152176.

APA

Łanocha, M., Spyra, A., Pawlus, Z., Miziołek, B.,  & Bergler-Czop, B. (2025). A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?. Dermatology Review/Przegląd Dermatologiczny, 112(1), 47-50. https://doi.org/10.5114/dr.2025.152176

Chicago

Łanocha, Mikołaj, Aleksandra Spyra, Zuzanna Pawlus, Bartosz Miziołek,  and Beata Bergler-Czop. 2025. "A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?". Dermatology Review/Przegląd Dermatologiczny 112 (1): 47-50. doi:10.5114/dr.2025.152176.

Harvard

Łanocha, M., Spyra, A., Pawlus, Z., Miziołek, B.,  and Bergler-Czop, B. (2025). A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?. Dermatology Review/Przegląd Dermatologiczny, 112(1), pp.47-50. https://doi.org/10.5114/dr.2025.152176

MLA

Łanocha, Mikołaj et al. "A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?." Dermatology Review/Przegląd Dermatologiczny, vol. 112, no. 1, 2025, pp. 47-50. doi:10.5114/dr.2025.152176.

Vancouver

Łanocha M, Spyra A, Pawlus Z, Miziołek B, Bergler-Czop B. A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?. Dermatology Review/Przegląd Dermatologiczny. 2025;112(1):47-50. doi:10.5114/dr.2025.152176.

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Introduction:
Kaposi sarcoma is a rare angioproliferative neoplasm associated with human herpesvirus 8 (HHV-8) present in five variants: classic, endemic, iatrogenic, epidemic, and men having sex with men without HIV infection.

Objective:
To present a rare case of Kaposi sarcoma with spontaneous remission of skin lesions without specific treatment, raising questions about whether it is a classic or iatrogenic variant exacerbated by the glucocorticosteroid therapy initiated in the meantime.

Case report:
A 63-year-old HIV-negative male presented with nodular lesions on his forearms, feet, and hands. Histological examination confirmed Kaposi sarcoma. Despite rapid lesion progression, the patient experienced significant remission without targeted oncological treatment. He had previously received dexamethasone therapy, and its discontinuation might have contributed to lesion regression.

Conclusions:
This case highlights the challenges in differentiating Kaposi sarcoma subtypes, particularly in patients on concurrent steroid therapy. Observed in our case remission may be linked to systemic glucocorticosteroids withdrawal, emphasizing their potential role in exacerbating the disease course.

keywords:

HIV, skin neoplasms, Kaposi sarcoma, herpesvirus 8

Indeks osobowy

A Case Report of Disseminated Kaposi Sarcoma with Spontaneous Regression in a HIV-negative Patient: Classic or Drug-induced Variant?

Mikołaj Łanocha 1 , Aleksandra Spyra 2 , Zuzanna Pawlus 2 , Bartosz Miziołek 1 , Beata Bergler-Czop 1

HIV, skin neoplasms, Kaposi sarcoma, herpesvirus 8

Mikołaj Łanocha

¹

,

Aleksandra Spyra

²

,

Zuzanna Pawlus

²

,

Bartosz Miziołek

¹

,

Beata Bergler-Czop

¹