Abstract
2/2005
vol. 43
Influence of tumor necrosis factor-αgen polymorphisms on susceptibility to, and severity of rheumatoid arthritis
Online publish date: 2005/04/27
Review of clinical data of European, Taiwan and Chilean population based on publications was done. Until now a total of nine single nucleotide polymorphisms (SNP) were identified. One of which is located in the first introne at position +489, one at position +70 in the 5’ untranslated region (UTR) and seven in the 5’ regulatory region, a region involved in the regulation of TNF gene transcription at position -163G/A, -238G/A, -244G/A, -308G/A, -376G/A, -857C/T,
-863C/A. The polymorphisms at position -238, -376, -308 and +489 were studied with particular attention. The polymorphisms at position -238 and -376 were found to be in strong linkage disequilibrium. In presented data no associations between the TNF-α gen polymorphisms and susceptibility to, or severity of, RA could be demonstrated in tested populations.
-863C/A. The polymorphisms at position -238, -376, -308 and +489 were studied with particular attention. The polymorphisms at position -238 and -376 were found to be in strong linkage disequilibrium. In presented data no associations between the TNF-α gen polymorphisms and susceptibility to, or severity of, RA could be demonstrated in tested populations.
Keywords
rheumatoid arthritis, tumor necrosis factor α, polymorphism
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