eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
5/2022
vol. 39
 
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abstract:
Original paper

Abrocitinib 100 mg versus 200 mg for atopic dermatitis: a meta-analysis of randomized controlled trials

Junqiao Wang
1
,
Yuanjuan Yang
2
,
Haitao Yang
3
,
Xiaojuan Fu
2

1.
Wenzhou Peace Plastic Surgery Hospital, Wenzhou, China
2.
Chongqing Medical and Pharmaceutical College, Chongqing, China
3.
Lunan Pharmaceutical Group Co., LTD
Adv Dermatol Allergol 2022; XXXIX (5): 908-912
Online publish date: 2022/03/27
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Introduction
It is elusive to compare the efficacy and safety of abrocitinib 100 mg versus 200 mg once daily in patients with atopic dermatitis.

Aim
This meta-analysis aims to explore the influence of abrocitinib 100 mg versus 200 mg on the treatment of atopic dermatitis.

Material and methods
Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library were systematically searched through July 2021. We included randomized controlled trials (RCTs) assessing the effect of abrocitinib 100 mg versus 200 mg for patients with atopic dermatitis.

Results
Four RCTs were included in the meta-analysis. Compared with abrocitinib 100 mg for atopic dermatitis, abrocitinib 200 mg had a remarkably positive impact on IGA response (OR = 1.78; 95% CI: 1.39–2.28; p < 0.00001), EASI-75 (OR = 2.03; 95% CI: 1.60–2.57; p < 0.00001), NRS response (OR = 1.97; 95% CI: 1.27–3.08; p = 0.003), and adverse events (OR = 1.43; 95% CI: 1.11–1.84; p = 0.005), but it showed no obvious influence on serious adverse events (OR = 0.59; 95% CI: 0.25–1.37; p = 0.22).

Conclusions
Abrocitinib 200 mg is better than abrocitinib 100 mg for the treatment of atopic dermatitis.

keywords:

abrocitinib, 100 mg, 200 mg, atopic dermatitis, randomized controlled trials

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