Abstract
Acute effects of different doses of malathion on the rat liver
- Department of Biochemistry, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, Turkey
- Department of Medical Biochemistry, Faculty of Medicine, Altinbas University, Turkey
- Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Turkey
- Department of Medical Laboratory, College of Health Care Services, Gazi University, Turkey
- Department of Pathology, Faculty of Medicine, Gazi University, Turkey
- Department of Medical Biochemistry, Institute of Health Science, Gazi University, Turkey
Aim of the study
Our study was designed to evaluate the acute effects of malathion on rat liver tissues.
Material and methods
The animals were divided into 4 groups of 6 animals/each. Group 1 (control group) received corn oil, while groups 2, 3, and 4 were given malathion dissolved in corn oil at a dose of 100, 200 and 400 mg/kg, respectively. 24 hours after malathion administration, animals were sacrificed and liver tissues were collected. The liver tissues were then analysed biochemically and histopathologically.
Results
Butyrylcholinesterase levels in groups 2, 3 and 4 were significantly lower than that of group 1. Total oxidant status and tumour necrosis factor alpha level were significantly increased in group 4 compared to group 1. Catalase activities of groups 3 and 4 were significantly higher than that of group 1. Arylesterase activity was significantly decreased in groups 3 and 4 compared to group 1. In groups 3 and 4, some vacuoles in hepatocytes were revealed and hydropic degeneration was observed in group 4.
Conclusions
Acute administrations of malathion results in hepatotoxicity in a dose-dependent manner.
Keywords
inflammation, oxidative stress, liver, malathion, histopathological examination
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