eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
3/2020
vol. 16
 
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abstract:
Original paper

Altered microRNA dynamics in acute coronary syndrome

Ewelina Kazimierczyk
1
,
Andrzej Eljaszewicz
2
,
Remigiusz Kazimierczyk
1
,
Marlena Tynecka
2
,
Paula Zembko
2
,
Ewa Tarasiuk
1
,
Karol Kaminski
1, 3
,
Bozena Sobkowicz
1
,
Marcin Moniuszko
2, 4
,
Agnieszka Tycinska
1

1.
Department of Cardiology, Medical University of Bialystok, Bialystok, Poland
2.
Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland
3.
Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, Poland
4.
Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Adv Interv Cardiol 2020; 16, 3 (61): 287–293
Online publish date: 2020/10/02
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Introduction
In the course of acute myocardial infarction (AMI) cardiomyocyte injury, activation and destruction of endothelial cells together with inflammation lead to miRNA expression alterations.

Aim
To assess levels of circulating cardiac-specific (miR-1) and endothelial-specific (miR-126) miRNAs in the acute phase of AMI and after a follow-up period.

Material and methods
Seventeen AMI patients (mean age: 64.24 ±13.83 years, mean left ventricle ejection fraction (LVEF): 42.6 ±9.65%), treated with primary percutaneous coronary intervention within the first 12 h, had plasma miRNAs isolated (quantitative real-time PCR, Exiqon) on admission and after 19.2 ±5.9 weeks. Measurements were also performed in a control group of healthy volunteers matched for age and sex.

Results
Concentrations of both miRNAs were significantly higher in AMI patients as compared to healthy controls: miR-1: 5.93 (3.15–14.92) vs. 1.46 (0.06–2.96), p = 0.04; miR-126: 4.5 (3.11–7.64) vs. 0.54 (0.36–0.99), p = 0.00003, respectively. Levels of both miRNAs significantly decreased after the follow-up period: miR-1: 5.93 (3.15–14.92) vs. 1.34 (0.04–2.34), p = 0.002; miR-126: 4.5 (3.11–7.64) vs. 1.18 (0.49–1.68), p = 0.0005). Moreover, miR-1 correlated positively with maximal troponin I concentration (r = 0.59, p = 0.02) and negatively with LVEF (r = –0.76, p = 0.0004).

Conclusions
In our study, miR-1 emerged as a marker of cardiomyocyte injury and loss of myocardial contractility, whereas dynamics of miR-126 concentration may reflect endothelial activation and damage in the most extreme stage of atherosclerosis, followed by angiogenesis in ischemic myocardium. However, to fully elucidate the role of miR-1 and miR-126 as biomarkers of AMI and future therapeutic targets, further research is required.

keywords:

microRNA, myocardial infarction, miR-126, miR-1

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