Abstract
5/2025
vol. 112
Case report
Annular Neutrophilic Variant of Pemphigus Foliaceus
- Department of Dermatology, Venereology and Leprosy, Sassoon General Hospital, B. J. Government Medical College, Pune, Maharashtra, India
Dermatol Rev/Przegl Dermatol 2025, 112, 331-335
Online publish date: 2025/12/30
Pemphigus belongs to autoimmune blistering disorders involving circulating antibodies against desmogleins, the proteins involved in keratinocyte adhesion. Pemphigus foliaceus, one of the pemphigus subtype, is characterised by IgG antibodies against desmoglein 1 present in the granular layer, manifesting as superficial epidermal acantholysis. Various presentations include pemphigus erythematosus and endemic pemphigus foliaceus (fogo selvagem). The annular neutrophilic variant is an uncommon presentation that may mimic other inflammatory or autoimmune conditions, including IgA pemphigus, subcorneal pustular dermatosis, and pustular psoriasis. We report the case of a 63-year-old female diagnosed with annular neutrophilic pemphigus foliaceus, successfully treated with colchicine and rituximab. This case highlights the importance of recognising atypical variants of pemphigus foliaceus and their necessary management.
Keywords
rituximab, pemphigus foliaceous, desmoglein 1, annular
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