Annular Neutrophilic Variant of Pemphigus Foliaceus

Vasudha Belgaumkar; Janhvi Shinde; Shekhar Pradhan; Kiran Dange; Neelam Bhatt; Sarthak Varshney

doi:10.5114/dr.2025.158602

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2025
vol. 112

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abstract:

Case report

Annular Neutrophilic Variant of Pemphigus Foliaceus

Vasudha Belgaumkar

¹

,

Janhvi B. Shinde

¹

,

Shekhar N. Pradhan

¹

,

Kiran Dange

¹

,

Neelam Kumari Bhatt

¹

,

Sarthak Varshney

¹

Department of Dermatology, Venereology and Leprosy, Sassoon General Hospital, B. J. Government Medical College, Pune, Maharashtra, India

Dermatol Rev/Przegl Dermatol 2025, 112, 331-335

DOI: https://doi.org/10.5114/dr.2025.158602

Online publish date: 2025/12/30

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Pemphigus belongs to autoimmune blistering disorders involving circulating antibodies against desmogleins, the proteins involved in keratinocyte adhesion. Pemphigus foliaceus, one of the pemphigus subtype, is characterised by IgG antibodies against desmoglein 1 present in the granular layer, manifesting as superficial epidermal acantholysis. Various presentations include pemphigus erythematosus and endemic pemphigus foliaceus (fogo selvagem). The annular neutrophilic variant is an uncommon presentation that may mimic other inflammatory or autoimmune conditions, including IgA pemphigus, subcorneal pustular dermatosis, and pustular psoriasis. We report the case of a 63-year-old female diagnosed with annular neutrophilic pemphigus foliaceus, successfully treated with colchicine and rituximab. This case highlights the importance of recognising atypical variants of pemphigus foliaceus and their necessary management.

keywords:

rituximab, pemphigus foliaceous, desmoglein 1, annular

Indeks osobowy

Annular Neutrophilic Variant of Pemphigus Foliaceus

Vasudha Belgaumkar 1 , Janhvi B. Shinde 1 , Shekhar N. Pradhan 1 , Kiran Dange 1 , Neelam Kumari Bhatt 1 , Sarthak Varshney 1

rituximab, pemphigus foliaceous, desmoglein 1, annular

Vasudha Belgaumkar

¹

,

Janhvi B. Shinde

¹

,

Shekhar N. Pradhan

¹

,

Kiran Dange

¹

,

Neelam Kumari Bhatt

¹

,

Sarthak Varshney

¹