Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class

Marta Lemieszek; Wojciech Rzeski

doi:10.5114/wo.2012.30055

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2012
vol. 16

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abstract:

Review paper

Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class

Marta Lemieszek

,

Wojciech Rzeski

Wspolczesna Onkol 2012; 16 (4): 285–289

DOI: https://doi.org/10.5114/wo.2012.30055

Online publish date: 2012/09/29

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Basidiomycete mushrooms represent a valuable source of biologically active compounds with anticancer properties. This feature is primarily attributed to polysaccharides and their derivatives. The anticancer potential of polysaccharides is linked to their origin, composition and chemical structure, solubility and method of isolation. Moreover, their activity can be significantly increased by chemical modifications. Anticancer effects of polysaccharides can be expressed indirectly (immunostimulation) or directly (cell proliferation inhibition and/or apopto-sis induction). Among the wide range of polysaccharides with documented anticancer properties, lentinan, polysaccharide-K (PSK) and schizophyllan deserve special attention. These polysaccharides for many years have been successfully applied in cancer treatment and their mechanism of action is the best known.

keywords:

Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class

Marta Lemieszek , Wojciech Rzeski

Basidiomycetes, anticancer properties, polysaccharides, lentinan, PSK, Krestin, schizophyllan

Marta Lemieszek

,

Wojciech Rzeski