Abstract
4/2010
vol. 5
Original paperThe influence of insulin resistance on plasma aldosterone concentration in obese persons with essential hypertension
Przegląd Kardiodabetologiczny 2010; 5 (3, 4): 138–143
Online publish date: 2011/01/13
Introduction: Obesity-related metabolic abnormalities are discussed intensively in a context of risk factors for cardiovascular diseases.
Aim : To assess plasma aldosterone concentration in abdominally obese adults with essential hypertension, according to insulin resistance observed.
Material and methods : Centrally obese (IDF 2005 criteria) adult Caucasians with essential hypertension, presenting no acute and chronic disease, using no medication, underwent clinical examination (i.e. body mass index [BMI], % of body fat, blood pressure). After oral glucose tolerance test (OGTT), assessing fasting (G0’) and 2-h (G120’) glycemia, newly diagnosed type 2 diabetics were excluded. Plasma lipids: T-C, HDL-C, TAG (bioMérieux), insulin (ELISA-BioSource) and aldosterone (RIA, Immunotech) concentrations were determined fasting. LDL-C was calculated due to Friedewald formula. Insulin-resistance indices, including IR = Ins 0’/G 0’ and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were estimated. Finally, non-IR group (n = 21; aged 48 ±10; 9 males, 12 females) with IR < 0.3 and IR group (n = 22; aged 46 ±11; 7 males, 15 females) with IR 0,3, with comparable prevalence of normoglycemia and pre-diabetes (50%), were studied. Statistical analysis was performed using Statistica 6.0 program.
Results : 1. In the IR group increased BMI, FAT and HOMA-IR were observed comparing with non-IR group. 2. The IR subjects presented higher aldosterone than non-IR individuals (92.9 ±62.8 pg/ml vs. 51.9 ±30.8 pg/ml; p = 0.032). 3. No correlations between aldosterone and other metabolic parameters were identified in neither studied groups.
Conclusions: The mechanisms of insulin resistance might contribute elevated plasma aldosterone concentration, which seems to be independent cardiovascular risk factors, in obese essential hypertensive subjects.
Aim : To assess plasma aldosterone concentration in abdominally obese adults with essential hypertension, according to insulin resistance observed.
Material and methods : Centrally obese (IDF 2005 criteria) adult Caucasians with essential hypertension, presenting no acute and chronic disease, using no medication, underwent clinical examination (i.e. body mass index [BMI], % of body fat, blood pressure). After oral glucose tolerance test (OGTT), assessing fasting (G0’) and 2-h (G120’) glycemia, newly diagnosed type 2 diabetics were excluded. Plasma lipids: T-C, HDL-C, TAG (bioMérieux), insulin (ELISA-BioSource) and aldosterone (RIA, Immunotech) concentrations were determined fasting. LDL-C was calculated due to Friedewald formula. Insulin-resistance indices, including IR = Ins 0’/G 0’ and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were estimated. Finally, non-IR group (n = 21; aged 48 ±10; 9 males, 12 females) with IR < 0.3 and IR group (n = 22; aged 46 ±11; 7 males, 15 females) with IR 0,3, with comparable prevalence of normoglycemia and pre-diabetes (50%), were studied. Statistical analysis was performed using Statistica 6.0 program.
Results : 1. In the IR group increased BMI, FAT and HOMA-IR were observed comparing with non-IR group. 2. The IR subjects presented higher aldosterone than non-IR individuals (92.9 ±62.8 pg/ml vs. 51.9 ±30.8 pg/ml; p = 0.032). 3. No correlations between aldosterone and other metabolic parameters were identified in neither studied groups.
Conclusions: The mechanisms of insulin resistance might contribute elevated plasma aldosterone concentration, which seems to be independent cardiovascular risk factors, in obese essential hypertensive subjects.
Keywords
aldosterone, obesity, insulin resistance, essential hypertension