eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
6/2019
vol. 106
 
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abstract:
Original article

Association of cytochrome P-45017 (T-34C) polymorphism and the risk of acne vulgaris: a meta-analysis

Mazaher Ramezani
1
,
Elisa Zavattaro
2
,
Masoud Sadeghi
3, 4

1.
Molecular Pathology Research Centre, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2.
Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont “Amedeo Avogadro”, Novara, Italy
3.
Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
4.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dermatol Rev/Przegl Dermatol 2019, 106, 591–602
Online publish date: 2020/02/07
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Objective
A meta-analysis evaluated the association of cytochrome P-45017 (CYP17) T-34C polymorphism with the risk of acne.

Material and methods
The databases (Scopus, Web of Science, PubMed, and Cochrane Library) were searched until September 2018.

Results
Out of 4 studies included in the meta-analysis, the odds ratio of C versus T in the patients compared to the controls was 1.42 (p = 0.02), in CC vs. TT it was 1.54 (p = 0.04), in TC vs. TT it was 1.46 (p = 0.12), in TC + CC vs. TT it was 1.55 (p = 0.04), and in CC vs. TT + TC it was 1.39 (p = 0.06). There was no acne risk related to CYP17 (T-34C) in any of the genetic models in Caucasian ethnicity, whereas in Asian ethnicity there was higher acne risk related to CYP17 (T-34C).

Conclusions
The results of the present meta-analysis showed that the presence of C allele and CC genotype of CYP17 polymorphism can be risk factors for acne, mainly in Asian ethnicity.

keywords:

acne, polymorphism, genetics, CYP17, ethnicity

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