Abstract
Association of cytochrome P-45017 (T-34C) polymorphism and the risk of acne vulgaris: a meta-analysis
- Molecular Pathology Research Centre, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
- Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont “Amedeo Avogadro”, Novara, Italy
- Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
- Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Objective
A meta-analysis evaluated the association of cytochrome P-45017 (CYP17) T-34C polymorphism with the risk of acne.
Material and methods
The databases (Scopus, Web of Science, PubMed, and Cochrane Library) were searched until September 2018.
Results
Out of 4 studies included in the meta-analysis, the odds ratio of C versus T in the patients compared to the controls was 1.42 (p = 0.02), in CC vs. TT it was 1.54 (p = 0.04), in TC vs. TT it was 1.46 (p = 0.12), in TC + CC vs. TT it was 1.55 (p = 0.04), and in CC vs. TT + TC it was 1.39 (p = 0.06). There was no acne risk related to CYP17 (T-34C) in any of the genetic models in Caucasian ethnicity, whereas in Asian ethnicity there was higher acne risk related to CYP17 (T-34C).
Conclusions
The results of the present meta-analysis showed that the presence of C allele and CC genotype of CYP17 polymorphism can be risk factors for acne, mainly in Asian ethnicity.
Keywords
acne, polymorphism, genetics, CYP17, ethnicity
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