eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2019
vol. 106
 
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abstract:
Original article

Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

Seyed Mohammadreza Niktabar
1
,
Seyed Mojtaba Latifi
1
,
Mansour Moghimi
2
,
Jamal Jafari-Nedooshan
1
,
Kazem Aghili
3
,
Seyed Mohsen Miresmaeili
4
,
Masoud Zare-Shehneh
5
,
Hossein Neamatzadeh
5, 6

1.
Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2.
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3.
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4.
Department of Biology, Science and Arts University, Yazd, Iran
5.
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6.
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Dermatol Rev/Przegl Dermatol 2019, 106, 268–279
Online publish date: 2019/08/24
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Introduction
Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results.

Objective
To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies.

Material and methods
We searched for eligible studies in the PubMed, Embase, and CNKI databases. A total of 40 case-control studies with 1,144 cases and 2,925 controls were included.

Results
The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma. However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk.

Conclusions
The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk.

keywords:

cutaneous melanoma, vitamin D receptor, polymorphism, meta-analysis

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