bBeta-blockers are competitive agonists of catecholamines acting on the beta adrenergic receptor. What are the limitations in using beta-blockers? The most important limitations are: acute heart failure, conduction disturbances, pulmonary side effects and metabolic disorders. Today, having a wide spectrum of beta-blockers, we can choose for each patient with accompanying diseases the best individual one. To treat heart failure the following beta-blockers are recommended: carvedilol, long-lasting metoprolol, bisoprolol and nebivolol in older patients. In the case of accompanying renal failure the preferred one should be metoprolol and carvedilol. Carvedilol should be avoided in renal failure with accompanying anaemia because it could intensify the anaemia. In metabolic syndrome the preferred beta-blocker is carvedilol. In patients with pulmonary diseases the most recommended are celiprolol and nebivolol.