Betulin: a natural product with promising anticancer activity
against colorectal cancer cells

Ewa Bębenek; Elwira Chrobak; Agnieszka Piechowska; Stanisław Głuszek; Stanisław Boryczka

doi:10.5114/ms.2020.102324

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2020
vol. 36

Send email

Copy url:

abstract:

Review paper

Betulin: a natural product with promising anticancer activity against colorectal cancer cells

Ewa Bębenek

¹

,

Elwira Chrobak

¹

,

Agnieszka Piechowska

²

,

Stanisław Głuszek

^{2, 3}

,

Stanisław Boryczka

¹

Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland

Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland

Department of Clinic General Oncological and Endocrinological Surgery, Regional Hospital, Kielce, Poland

Medical Studies/Studia Medyczne 2020; 36 (4): 298–302

DOI: https://doi.org/10.5114/ms.2020.102324

Online publish date: 2020/12/31

View full text Get citation

PlumX metrics:

Colorectal cancer is the third most frequently diagnosed type of cancer in men, while it ranks second in women. The high mortality rate of people with colorectal cancer is due to the advanced stage at diagnosis and the low selectivity of the currently used cytostatics. One of the important directions in searching for new anticancer substances is research of natural origin compounds. Betulin is a promising substance from this group, showing activity against colon cancer cells with low toxicity. Studies of betulin carried out in the aspect of the evaluation of this direction of activity concerned human tumor cell lines Col2, SW707, DLD-1, HT29 and HCT116. It was also important to determine the molecular mechanisms of action of this triterpene in colon cancer cells.

keywords:

Betulin: a natural product with promising anticancer activity against colorectal cancer cells

Ewa Bębenek 1 , Elwira Chrobak 1 , Agnieszka Piechowska 2 , Stanisław Głuszek 2, 3 , Stanisław Boryczka 1

colorectal cancer, betulin, natural products

Ewa Bębenek

¹

,

Elwira Chrobak

¹

,

Agnieszka Piechowska

²

,

Stanisław Głuszek

^{2, 3}

,

Stanisław Boryczka

¹