Bortezomib-induced painful neuropathy in patients with multiple myeloma

Małgorzata Bilińska; Lidia Usnarska-Zubkiewicz; Anna Pokryszko-Dragan

doi:10.5114/wo.2013.37214

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2013
vol. 17

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abstract:

Review paper

Bortezomib-induced painful neuropathy in patients with multiple myeloma

Małgorzata Bilińska

,

Lidia Usnarska-Zubkiewicz

,

Anna Pokryszko-Dragan

Contemp Oncol (Pozn) 2013; 17 (5): 421–426

DOI: https://doi.org/10.5114/wo.2013.37214

Online publish date: 2013/10/11

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Neurotoxicity towards the peripheral nervous system which appears clinically in the form of painful neuropathy is an essential dose-limiting factor during the treatment of multiple myeloma. In this review article different forms of this painful neuropathy are presented together with currently available diagnostic tools which are usually applied to confirm the diagnosis. Also, the most often used neurological scales estimating neurological deficit are presented. Special attention is paid to the management of the reversibility of bortezomib-induced neuropathic pain.

keywords:

Bortezomib-induced painful neuropathy in patients with multiple myeloma

Małgorzata Bilińska , Lidia Usnarska-Zubkiewicz , Anna Pokryszko-Dragan

multiple myeloma, bortezomib, bortezomib induced neuropathy

Małgorzata Bilińska

,

Lidia Usnarska-Zubkiewicz

,

Anna Pokryszko-Dragan