Full text
2/2025
vol. 41
Review article
Caffeine and neurodegenerative diseases
- Provincial Clinical Hospital No. 2 named after St. Jadwiga the Queen in Rzeszów, Poland; Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie, Polska
- St. Vincent de Paul Hospital, Gdynia, Poland; Szpital św. Wincentego a Paulo, Gdynia, Polska
- Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland; Szpital Uniwersytecki nr 2 im. dr Jana Biziela, Bydgoszcz, Polska
- Provincial Specialist Hospital in Wrocław, Department of Ophthalmology, Poland; Wojewódzki Szpital Specjalistyczny we Wrocławiu, Oddział Okulistyczny, Polska
- Department of Cardiology, PIM MSWiA, Warsaw, Poland; Klinika Kardiologii, PIM MSWiA, Warszawa, Polska
- Department of Orthodontics and Masticatory Organ Dysfunction, University of Medical Sciences in Poznań, Poland; Klinika Ortodoncji i Dysfunkcji Narządu Żucia, Uniwersytet Medyczny w Poznaniu, Polska
- Jan Mikulicz-Radecki University Clinical Hospital in Wrocław, Poland; Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Polska
- Consultative Prosthodontics Department, Provincial Dental Clinic named after Dr. Zbigniew Żak, MD, in Krakow, Poland; Konsultacyjna Poradnia Protetyki Stomatologicznej, Wojewódzka Przychodnia Stomatologiczna im. dr. n. med. Zbigniewa Żaka w Krakowie, Polska
Farmakoterapia w Psychiatrii i Neurologii 2025
Data publikacji online: 2026/04/28
Article file
- Abalo R. Coffee and caffeine consumption for human health. Nutrients 2021; 13 (9): 2918.
- Almosawi S, Baksh H, Qareeballa A. et al. Acute administration of caffeine: the effect on motor coordination, higher brain cognitive functions, and the social behavior of BLC57 mice. Behavioral Sciences 2018; 8: 65.
- Badshah H, Ikram M, Ali W et al. Caffeine may abrogate LPS-induced oxidative stress and neuroinflammation by regulating Nrf2/TLR4 in adult mouse brains. Biomolecules 2019; 9: 719.
- Czarniecka-Skubina E, Pielak M, Sałek P, Korzeniowska-Ginter R and Owczarek T. Consumer choices and habits related to coffee consumption by Poles. International Journal of Environmental Research and Public Health 2021; 18 (8): 3948.
- Drake C, Roehrs T, Shambroom J et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine 2013; 9 (11): 1195–1200.
- Evans J, Richards JR and Battisti AS. Caffeine. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
- Fuller DT, Smith ML and Boolani A. Trait energy and fatigue modify the effects of caffeine on mood, cognitive and fine-motor task performance: a post-hoc study. Nutrients 2021; 13: 412.
- Herden L and Weissert R. The effect of coffee and caffeine consumption on patients with multiple sclerosis-related fatigue. Nutrients 2020; 12: 2262.
- Hong CT, Chan L and Bai CH. The effect of caffeine on the risk and progression of Parkinson’s disease: a meta-analysis. Nutrients 2020; 12: 1860.
- IARC Working Group. Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1991, Volume 51. Lyon: International Agency for Research on Cancer.
- Ikram M, Park TJ, Ali T et al. Antioxidant and neuroprotective effects of caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the role of Nrf2 and A2AR signaling. Antioxidants 2020; 9: 902.
- Janitschke D, Lauer AA, Bachmann CM et al. Methylxanthines and neurodegenerative diseases: An update. Nutrients 2021; 13: 803.
- Jung S, Gu S, Lee S-H and Jeong Y. Effect of roasting degree on the antioxidant properties of espresso and drip coffee extracted from Coffea arabica cv. Java. Applied Sciences 2021; 11 (15): 7025.
- Kolahdouzan M and Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neuroscience & Therapeutics 2017; 23 (4): 272–290.
- LiverTox. LiverTox: Clinical and research information on drug-induced liver injury [online]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases 2012.
- Murray A and Traylor J. Caffeine toxicity. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
- Nehlig A. Interindividual differences in caffeine metabolism and factors driving caffeine consumption. Pharmacological Reviews 2018; 70 (2): 384–411.
- Pohanka M and Dobes P. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International Journal of Molecular Sciences 2013; 14: 9873–9882.
- Reichert C. Daily caffeine intake induces concentration-dependent medial temporal plasticity in humans: a multimodal double-blind randomized controlled trial. Cerebral Cortex 2021; 31 (6): pp. 3096–3106.
- Sajadi-Ernazarova KR, Anderson J, Dhakal A et al. Caffeine withdrawal. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
- Schepici G, Silvestro S, Bramanti P et al. Caffeine: an overview of its beneficial effects in experimental models and clinical trials of Parkinson’s disease. International Journal of Molecular Sciences 2020; 21: 4766.
- Shochat T, Hadish-Shogan S, Yosipof MB et al. Burnout, sleep, and sleepiness during day and night shifts in transition from 8- to 12-hour shift rosters among airline ground crew managers. Clocks & Sleep 2019; 1 (2): 226–239.
- Socała K, Szopa A, Serefko A et al. Neuroprotective effects of coffee bioactive compounds: A review. International Journal of Molecular Sciences 2021; 22: 107.
- Sohail AA, Ortiz F, Varghese T et al. The cognitive-enhancing outcomes of caffeine and L-theanine: A systematic review. Cureus 2021; 13 (12): p.e20828.
- Stachyshyn S, Rutherfurd-Markwick K, Ali A and Wham C. Caffeine related risk among tertiary students in New Zealand. Proceedings 2019; 8 (1): 24.
- Turner S, Rutherfurd-Markwick K, Ali A and Wham C. Caffeinated product consumption among NZ adolescents: habits and motivators for consumption. Proceedings 2019; 37 (1): 29.
- Ueda K and Nakao M. Effects of transpulmonary administration of caffeine on brain activity in healthy men. Brain Sciences 2019; 9: 222.
- Yeomans MR, Ripley T, Davies LH et al. Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology 2002; 164 (3): 241–249.
- Zwilling M, Theiss C and Matschke V. Caffeine and NAD+ improve motor neural integrity of dissociated Wobbler cells in vitro. Antioxidants 2020; 9: 460.
