Farmakoterapia w Psychiatrii i Neurologii
eISSN: 2449-9315
ISSN: 1234-8279
Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii
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2/2025
vol. 41
 
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Artykuł przeglądowy

Kofeina a choroby neurodegeneracyjne

Adam Łabuda
1
,
Elżbieta Tokarczyk
2
,
Daria Ziemińska
2
,
Rafał Burczyk
3
,
Zuzanna Bentkowska
4
,
Jakub Kuciński
5
,
Natalie Górna
6
,
Maciej Bugajewski
,
Aleksandra Bogoń
7
,
Alicja Stępień
8

  1. Provincial Clinical Hospital No. 2 named after St. Jadwiga the Queen in Rzeszów, Poland; Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie, Polska
  2. St. Vincent de Paul Hospital, Gdynia, Poland; Szpital św. Wincentego a Paulo, Gdynia, Polska
  3. Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland; Szpital Uniwersytecki nr 2 im. dr Jana Biziela, Bydgoszcz, Polska
  4. Provincial Specialist Hospital in Wrocław, Department of Ophthalmology, Poland; Wojewódzki Szpital Specjalistyczny we Wrocławiu, Oddział Okulistyczny, Polska
  5. Department of Cardiology, PIM MSWiA, Warsaw, Poland; Klinika Kardiologii, PIM MSWiA, Warszawa, Polska
  6. Department of Orthodontics and Masticatory Organ Dysfunction, University of Medical Sciences in Poznań, Poland; Klinika Ortodoncji i Dysfunkcji Narządu Żucia, Uniwersytet Medyczny w Poznaniu, Polska
  7. Jan Mikulicz-Radecki University Clinical Hospital in Wrocław, Poland; Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Polska
  8. Consultative Prosthodontics Department, Provincial Dental Clinic named after Dr. Zbigniew Żak, MD, in Krakow, Poland; Konsultacyjna Poradnia Protetyki Stomatologicznej, Wojewódzka Przychodnia Stomatologiczna im. dr. n. med. Zbigniewa Żaka w Krakowie, Polska
Farmakoterapia w Psychiatrii i Neurologii 2025
DOI: https://doi.org/10.5114/fpn.2025.159502
Data publikacji online: 2026/04/28
Plik artykułu:
- Caffeine and neuro­degenerative diseases .pdf  [0.51 MB]
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Metryki PlumX:
 
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7. Fuller DT, Smith ML and Boolani A. Trait energy and fatigue modify the effects of caffeine on mood, cognitive and fine-motor task performance: a post-hoc study. Nutrients 2021; 13: 412.
8. Herden L and Weissert R. The effect of coffee and caffeine consumption on patients with multiple sclerosis-related fatigue. Nutrients 2020; 12: 2262.
9. Hong CT, Chan L and Bai CH. The effect of caffeine on the risk and progression of Parkinson’s disease: a meta-analysis. Nutrients 2020; 12: 1860.
10. IARC Working Group. Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1991, Volume 51. Lyon: International Agency for Research on Cancer.
11. Ikram M, Park TJ, Ali T et al. Antioxidant and neuroprotective effects of caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the role of Nrf2 and A2AR signaling. Antioxidants 2020; 9: 902.
12. Janitschke D, Lauer AA, Bachmann CM et al. Methylxanthines and neurodegenerative diseases: An update. Nutrients 2021; 13: 803.
13. Jung S, Gu S, Lee S-H and Jeong Y. Effect of roasting degree on the antioxidant properties of espresso and drip coffee extracted from Coffea arabica cv. Java. Applied Sciences 2021; 11 (15): 7025.
14. Kolahdouzan M and Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neuroscience & Therapeutics 2017; 23 (4): 272–290.
15. LiverTox. LiverTox: Clinical and research information on drug-induced liver injury [online]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases 2012.
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18. Pohanka M and Dobes P. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International Journal of Molecular Sciences 2013; 14: 9873–9882.
19. Reichert C. Daily caffeine intake induces concentration-dependent medial temporal plasticity in humans: a multimodal double-blind randomized controlled trial. Cerebral Cortex 2021; 31 (6): pp. 3096–3106.
20. Sajadi-Ernazarova KR, Anderson J, Dhakal A et al. Caffeine withdrawal. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
21. Schepici G, Silvestro S, Bramanti P et al. Caffeine: an overview of its beneficial effects in experimental models and clinical trials of Parkinson’s disease. International Journal of Molecular Sciences 2020; 21: 4766.
22. Shochat T, Hadish-Shogan S, Yosipof MB et al. Burnout, sleep, and sleepiness during day and night shifts in transition from 8- to 12-hour shift rosters among airline ground crew managers. Clocks & Sleep 2019; 1 (2): 226–239.
23. Socała K, Szopa A, Serefko A et al. Neuroprotective effects of coffee bioactive compounds: A review. International Journal of Molecular Sciences 2021; 22: 107.
24. Sohail AA, Ortiz F, Varghese T et al. The cognitive-enhancing outcomes of caffeine and L-theanine: A systematic review. Cureus 2021; 13 (12): p.e20828.
25. Stachyshyn S, Rutherfurd-Markwick K, Ali A and Wham C. Caffeine related risk among tertiary students in New Zealand. Proceedings 2019; 8 (1): 24.
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