Farmakoterapia w Psychiatrii i Neurologii

Pełna treść

2/2025 vol. 41
Artykuł przeglądowy

Kofeina a choroby neurodegeneracyjne

Adam Łabuda 1
,
Elżbieta Tokarczyk 2
,
Daria Ziemińska 2
,
Rafał Burczyk 3
,
Zuzanna Bentkowska 4
,
Jakub Kuciński 5
,
Natalie Górna 6
,
Maciej Bugajewski
,
Aleksandra Bogoń 7
,
Alicja Stępień 8
  1. Provincial Clinical Hospital No. 2 named after St. Jadwiga the Queen in Rzeszów, Poland; Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie, Polska
  2. St. Vincent de Paul Hospital, Gdynia, Poland; Szpital św. Wincentego a Paulo, Gdynia, Polska
  3. Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland; Szpital Uniwersytecki nr 2 im. dr Jana Biziela, Bydgoszcz, Polska
  4. Provincial Specialist Hospital in Wrocław, Department of Ophthalmology, Poland; Wojewódzki Szpital Specjalistyczny we Wrocławiu, Oddział Okulistyczny, Polska
  5. Department of Cardiology, PIM MSWiA, Warsaw, Poland; Klinika Kardiologii, PIM MSWiA, Warszawa, Polska
  6. Department of Orthodontics and Masticatory Organ Dysfunction, University of Medical Sciences in Poznań, Poland; Klinika Ortodoncji i Dysfunkcji Narządu Żucia, Uniwersytet Medyczny w Poznaniu, Polska
  7. Jan Mikulicz-Radecki University Clinical Hospital in Wrocław, Poland; Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Polska
  8. Consultative Prosthodontics Department, Provincial Dental Clinic named after Dr. Zbigniew Żak, MD, in Krakow, Poland; Konsultacyjna Poradnia Protetyki Stomatologicznej, Wojewódzka Przychodnia Stomatologiczna im. dr. n. med. Zbigniewa Żaka w Krakowie, Polska
Farmakoterapia w Psychiatrii i Neurologii 2025
DOI: https://doi.org/10.5114/fpn.2025.159502
Data publikacji online: 2026/04/28
Plik artykułu
Caffeine and neuro­degenerative diseases .pdf
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
  1. Abalo R. Coffee and caffeine consumption for human health. Nutrients 2021; 13 (9): 2918.
  2. Almosawi S, Baksh H, Qareeballa A. et al. Acute administration of caffeine: the effect on motor coordination, higher brain cognitive functions, and the social behavior of BLC57 mice. Behavioral Sciences 2018; 8: 65.
  3. Badshah H, Ikram M, Ali W et al. Caffeine may abrogate LPS-induced oxidative stress and neuroinflammation by regulating Nrf2/TLR4 in adult mouse brains. Biomolecules 2019; 9: 719.
  4. Czarniecka-Skubina E, Pielak M, Sałek P, Korzeniowska-Ginter R and Owczarek T. Consumer choices and habits related to coffee consumption by Poles. International Journal of Environmental Research and Public Health 2021; 18 (8): 3948.
  5. Drake C, Roehrs T, Shambroom J et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine 2013; 9 (11): 1195–1200.
  6. Evans J, Richards JR and Battisti AS. Caffeine. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
  7. Fuller DT, Smith ML and Boolani A. Trait energy and fatigue modify the effects of caffeine on mood, cognitive and fine-motor task performance: a post-hoc study. Nutrients 2021; 13: 412.
  8. Herden L and Weissert R. The effect of coffee and caffeine consumption on patients with multiple sclerosis-related fatigue. Nutrients 2020; 12: 2262.
  9. Hong CT, Chan L and Bai CH. The effect of caffeine on the risk and progression of Parkinson’s disease: a meta-analysis. Nutrients 2020; 12: 1860.
  10. IARC Working Group. Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1991, Volume 51. Lyon: International Agency for Research on Cancer.
  11. Ikram M, Park TJ, Ali T et al. Antioxidant and neuroprotective effects of caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the role of Nrf2 and A2AR signaling. Antioxidants 2020; 9: 902.
  12. Janitschke D, Lauer AA, Bachmann CM et al. Methylxanthines and neurodegenerative diseases: An update. Nutrients 2021; 13: 803.
  13. Jung S, Gu S, Lee S-H and Jeong Y. Effect of roasting degree on the antioxidant properties of espresso and drip coffee extracted from Coffea arabica cv. Java. Applied Sciences 2021; 11 (15): 7025.
  14. Kolahdouzan M and Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neuroscience & Therapeutics 2017; 23 (4): 272–290.
  15. LiverTox. LiverTox: Clinical and research information on drug-induced liver injury [online]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases 2012.
  16. Murray A and Traylor J. Caffeine toxicity. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
  17. Nehlig A. Interindividual differences in caffeine metabolism and factors driving caffeine consumption. Pharmacological Reviews 2018; 70 (2): 384–411.
  18. Pohanka M and Dobes P. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International Journal of Molecular Sciences 2013; 14: 9873–9882.
  19. Reichert C. Daily caffeine intake induces concentration-dependent medial temporal plasticity in humans: a multimodal double-blind randomized controlled trial. Cerebral Cortex 2021; 31 (6): pp. 3096–3106.
  20. Sajadi-Ernazarova KR, Anderson J, Dhakal A et al. Caffeine withdrawal. In: StatPearls 2023 [online]. Treasure Island (FL): StatPearls Publishing.
  21. Schepici G, Silvestro S, Bramanti P et al. Caffeine: an overview of its beneficial effects in experimental models and clinical trials of Parkinson’s disease. International Journal of Molecular Sciences 2020; 21: 4766.
  22. Shochat T, Hadish-Shogan S, Yosipof MB et al. Burnout, sleep, and sleepiness during day and night shifts in transition from 8- to 12-hour shift rosters among airline ground crew managers. Clocks & Sleep 2019; 1 (2): 226–239.
  23. Socała K, Szopa A, Serefko A et al. Neuroprotective effects of coffee bioactive compounds: A review. International Journal of Molecular Sciences 2021; 22: 107.
  24. Sohail AA, Ortiz F, Varghese T et al. The cognitive-enhancing outcomes of caffeine and L-theanine: A systematic review. Cureus 2021; 13 (12): p.e20828.
  25. Stachyshyn S, Rutherfurd-Markwick K, Ali A and Wham C. Caffeine related risk among tertiary students in New Zealand. Proceedings 2019; 8 (1): 24.
  26. Turner S, Rutherfurd-Markwick K, Ali A and Wham C. Caffeinated product consumption among NZ adolescents: habits and motivators for consumption. Proceedings 2019; 37 (1): 29.
  27. Ueda K and Nakao M. Effects of transpulmonary administration of caffeine on brain activity in healthy men. Brain Sciences 2019; 9: 222.
  28. Yeomans MR, Ripley T, Davies LH et al. Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology 2002; 164 (3): 241–249.
  29. Zwilling M, Theiss C and Matschke V. Caffeine and NAD+ improve motor neural integrity of dissociated Wobbler cells in vitro. Antioxidants 2020; 9: 460.
ZGŁASZANIE PRAC
Udostępnij
without publication fees
without publication fees
Zintergrowane z
Zasady redakcyjne
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications