Adverse reactions after applying cosmetics constitute an increasing clinical problem. Fragrances are the principal allergens of cosmetic products and together with preservatives are among the top 5 most frequent contact allergens. The contemporary diagnostics of contact allergy to fragrances is based on patch tests with fragrance mix. The purpose of the study was to report a case of high contact sensitivity with accompanying toxic reaction to fragrance mix I and II and Lyral. Patch tests were performed with the Standard European Set of contact allergens. The first reading after 48 h was positive (+++) with fragrance mix I, whereas within the area with Lyral and fragrance mix II single blisters containing clearly visible light yellow liquid were observed. After 72 h no variation of the test result was recorded.