Primary cardiac tumours are rare, with a reported prevalence of 0.001–0.3% of routine autopsies. More than three-quarters of them are benign, with myxoma as the most common histological type. The malignant primary tumours of the heart are angiosarcomas, rhabdomyosarcoma, osteosarcoma, leiomyosarcoma, undifferentiated sarcoma and primary cardiac lymphoma. The angiosarcoma is an extremely rare neoplasm has a very poor prognosis for recovery because of late diagnosis, aggressive biological behaviour and minimal response to chemotherapy. The mean survive is six to eleven months. We reported two cases treated in the Department of Oncology and Radiotherapy at the University Hospital in Pilsen.