eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
2/2010
vol. 27
 
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abstract:

Case report
Specific skin manifestation of B-cell chronic lymphocytic leukaemia

Grażyna Chodorowska
,
Anna Szponar
,
Agnieszka Gerkowicz
,
Maria Juszkiewicz-Borowiec
,
Monika Podhorecka

Post Dermatol Alergol 2010; XXVII, 2: 140–144
Online publish date: 2010/05/17
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B-cell chronic lymphocytic leukaemia (B-CLL) is the most common type of leukaemia. Besides systemic symptoms, patients may present various forms of skin manifestation. Considering the variety of cutaneous symptomatology, skin lesions in B-CLL patients are divided into specific and non-specific, based on the presence or absence of leukaemic infiltration in the skin. Nowadays it is thought that post-zoster lymphoproliferative skin changes in CLL patients might be a specific cutaneous manifestation of chronic lymphocytic leukaemia. This paper presents a case of a 71-year old male patient with B-cell chronic lymphocytic leukaemia. The patient’s chemotherapy regimen was discontinued due to haemorrhagic zoster followed by dorsal skin ulcers. The patient was admitted to the Dermatological Department and a skin biopsy was performed, which revealed the leukaemic infiltration. Viral aetiology of the ulcers was excluded. The patient was thus re-qualified for chemotherapy. Patients with chronic lymphocytic leukaemia are more prone to numerous infections of various aetiology. It is worth considering that the skin ulcers may be regarded as a complication of these infections, as well as may be a specific cutaneous manifestation of the leukaemia.
keywords:

herpes zoster, B-CLL, chronic lymphocytic leukaemia

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