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ISSN: 2392-1099
Clinical and Experimental Hepatology
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1/2023
vol. 9
 
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abstract:
Original paper

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Hossein Niknahad
1
,
Pooria Sayar Mehrabani
1
,
Abdollah Arjmand
2
,
Sepideh Alidaee
1
,
Sahra Mazloomi
1
,
Parinaz Ahmadi
1
,
Narges Abdoli
3
,
Mohsen Saeed
1
,
Mohammad Rezaei
1
,
Mohammad Mehdi Ommati
1, 4
,
Reza Heidari
1

  1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. Iran Food and Drug Administration, Department of Science and Medical Education, Ministry of Health, Tehran, Iran
  4. Department of Life Sciences, Shanxi Agricultural University, Shanxi, Taigu, China
Clin Exp HEPATOL 2023; 9, 1: 79-93
DOI: https://doi.org/10.5114/ceh.2023.126028
Online publish date: 2023/03/24
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Aim of the study:
Cholestasis/cirrhosis could induce erythrocyte lysis. The incidence of various types of anemia in cirrhosis is approx. 75%. Several studies have mentioned the pivotal role of oxidative stress in this complication. Taurine (TAU) is the human body’s most abundant free amino acid. TAU is known as a robust cell membrane stabilizer. Many studies have mentioned that TAU could counteract oxidative stress in various experimental models. The current study was intended to evaluate the effect of TAU on erythrocytes in cirrhotic rats.

Material and methods
Bile duct ligation (BDL) surgery was carried out on rats. Then, complete blood count (CBC), hemoglobin (Hgb), hematocrit (HTC), and erythrocytes’ G6PD, catalase (CAT), and superoxide dismutase (SOD) activity were measured. Moreover, biomarkers of oxidative stress were assessed, and the erythrocytes’ morphological changes were monitored in the cirrhotic mice exposed to TAU (0.25%, 0.5%, and 1% w : v in drinking water).

Results:
Significant changes in the assessed erythrocyte parameters (G6PD activity, Hgb, HTC, and erythrocyte count) and red blood cells (RBC) morphological alterations were detected on day 42 after BDL surgery. Biomarkers of oxidative stress also did not change at the time points, except on post-BDL days 28 and 42. A significant decrease in blood parameters was evident at post-BDL day 42. All doses of TAU (0.25%, 0.5%, and 1% w : v in drinking water) significantly improved erythrocyte parameters and encountered oxidative stress in the erythrocytes of cirrhotic animals.

Conclusions:
These data indicate that TAU could be a safe agent to mitigate cirrhosis-induced erythrocyte damage and anemia. Further investigations are necessary to prove this in clinical settings.

keywords:

anemia, bile acids, cholestasis, cirrhosis, oxidative stress, red blood cells
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