Prolonged glucocorticosteroid therapy is the most common cause of secondary osteoporosis, named glucocorticoid-induced osteoporosis. It is estimated that 30 to 50% of chronic glucocorticosteroid users experience vertebral or hip fractures. Prevention of osteoporosis is a very important public health concern. Dermatologists are among the leading prescribers of oral glucocorticosteroids; therefore, this topic is of utmost importance. Dermatological patients treated with glucocorticosteroids for longer than 3 months should receive prophylactic treatment to decrease the risk of bone loss. When glucocorticoids are used for a period shorter than 3 months, current literature does not suggest prophylaxis. All patients starting glucocorticosteroid treatment should be given instructions on general measures for prevention of bone loss.