Current look at effects of long-term proton pump inhibitors therapy

Barbara Skrzydło-Radomańska

Abstract

10/2005 vol. 8

Current look at effects of long-term proton pump inhibitors therapy

Barbara Skrzydło-Radomańska

Przew Lek 2005; 10; 52-57

Online publish date: 2005/12/22

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AMA

Skrzydło-Radomańska B. Current look at effects of long-term proton pump inhibitors therapy. Przewodnik Lekarza/Guide for GPs. 2005:52-57.

APA

Skrzydło-Radomańska, B. (2005). Current look at effects of long-term proton pump inhibitors therapy. Przewodnik Lekarza/Guide for GPs, 52-57.

Chicago

Skrzydło-Radomańska, Barbara. 2005. "Current look at effects of long-term proton pump inhibitors therapy". Przewodnik Lekarza/Guide for GPs: 52-57.

Harvard

Skrzydło-Radomańska, B. (2005). Current look at effects of long-term proton pump inhibitors therapy. Przewodnik Lekarza/Guide for GPs, pp.52-57.

MLA

Skrzydło-Radomańska, Barbara. "Current look at effects of long-term proton pump inhibitors therapy." Przewodnik Lekarza/Guide for GPs, 2005, pp. 52-57.

Vancouver

Skrzydło-Radomańska B. Current look at effects of long-term proton pump inhibitors therapy. Przewodnik Lekarza/Guide for GPs. 2005:52-57.

Introduction of proton pump inhibitors (PPI) provided an important progress in treatment of the acid-related diseases. PPI are largely administered andand frequently used in long-term therapy. Hypergastrinaemia induced by PPI may lead in human to enterochromaffin-like cells hyperplasia. No neoplastic changes have been reported after more than a decade of use. Fat and mineral bioavailability remain unaltered by PPI therapy. However absorption and profound acid suppression for many years may lead to vitamin B₁₂ deficiency.

Keywords

proton pump inhibitors, long-term therapy

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