Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre

Alicja Adaszewska; Katarzyna Woźniak; Agnieszka Kalińska-Bienias; Katarzyna Smolarczyk; Cezary Kowalewski

doi:10.5114/ada.2020.99972

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Diagnostics of autoimmune blistering disorders: an experience of a single tertiary referral centre

Alicja Adaszewska

¹

,

Katarzyna Woźniak

¹

,

Agnieszka Kalińska-Bienias

¹

,

Katarzyna Smolarczyk

²

,

Cezary Kowalewski

¹

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland

Department of Dermatology and Venereology, Medical University of Warsaw, Warsaw, Poland

Adv Dermatol Allergol 2022; XXXIX (3): 446-453

DOI: https://doi.org/10.5114/ada.2020.99972

Online publish date: 2020/11/04

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AMA

Adaszewska A, Woźniak K, Kalińska-Bienias A, Smolarczyk K, Kowalewski C. Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(3):446-453. doi:10.5114/ada.2020.99972.

APA

Adaszewska, A., Woźniak, K., Kalińska-Bienias, A., Smolarczyk, K.,  & Kowalewski, C. (2022). Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(3), 446-453. https://doi.org/10.5114/ada.2020.99972

Chicago

Adaszewska, Alicja, Katarzyna Woźniak, Agnieszka Kalińska-Bienias, Katarzyna Smolarczyk,  and Cezary Kowalewski. 2022. "Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (3): 446-453. doi:10.5114/ada.2020.99972.

Harvard

Adaszewska, A., Woźniak, K., Kalińska-Bienias, A., Smolarczyk, K.,  and Kowalewski, C. (2022). Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(3), pp.446-453. https://doi.org/10.5114/ada.2020.99972

MLA

Adaszewska, Alicja et al. "Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 3, 2022, pp. 446-453. doi:10.5114/ada.2020.99972.

Vancouver

Adaszewska A, Woźniak K, Kalińska-Bienias A, Smolarczyk K, Kowalewski C. Diagnostics of autoimmune blistering disorders:
an experience of a single tertiary referral centre. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(3):446-453. doi:10.5114/ada.2020.99972.

Autoimmune blistering disorders (AIBD) include a heterogeneous group of diseases characterized by the presence of autoantibodies against the structural antigens of the skin and mucous membranes. The gold standard of AIBD diagnostics is the detection of in vivo bound IgG/IgA and/or complement component 3 in the direct immunofluorescence of a perilesional biopsy. Various immunological techniques such as indirect immunofluorescence of different tissue substrates including monkey oesophagus, salt split skin, recombinant proteins of epidermis and basement membrane zone as well as ELISA systems and immunoblotting are used to characterize target antigens. Proper and early diagnosis is crucial for both treatment and prognosis since some AIBD may be associated with a malignant neoplasm.

keywords:

Diagnostics of autoimmune blistering disorders: an experience of a single tertiary referral centre

Alicja Adaszewska 1 , Katarzyna Woźniak 1 , Agnieszka Kalińska-Bienias 1 , Katarzyna Smolarczyk 2 , Cezary Kowalewski 1

immunofluorescence, autoimmune blistering disorders, pemphigus, pemphigoid, BIOCHIP, ELISA

Alicja Adaszewska

¹

,

Katarzyna Woźniak

¹

,

Agnieszka Kalińska-Bienias

¹

,

Katarzyna Smolarczyk

²

,

Cezary Kowalewski

¹