Does IL-31 level have more significance in chronic
urticaria, when compared with IL-33 level?

Güzin Özden; Didar Acık; Asım Tekin; Mehmet Bankir; Leyla Cevirme; Yavuzalp Solak

doi:10.5114/ada.2025.155417

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Does IL-31 level have more significance in chronic urticaria, when compared with IL-33 level?

Güzin Özden

¹

,

Didar Yanardag Acık

²

,

Asım Tekin

³

,

Mehmet Bankir

⁴

,

Leyla Cevirme

⁵

,

Yavuzalp Solak

⁶

Division of Immunology and Allergy Diseases, Health Sciences University Adana City Training and Research Hospital, Adana, Turkey
Department of Haematology, Health Sciences University Adana City Training and Research Hospital, Adana, Turkey
Department of Internal Medicine, Suruc State Hospital Internal Medicine Şanlıurfa, Turkey
Department of Internal Medicine, Health Sciences University Adana City Training and Research Hospital, Adana, Turkey
Adana City Training and Research Hospital, Adana, Turkey
Department of Public Health, Sereflikochisar District Health Directorate, Ankara, Turkey

Adv Dermatol Allergol 2025; XLII (5): 453–459

DOI: https://doi.org/10.5114/ada.2025.155417

Online publish date: 2025/10/20

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Introduction
Chronic urticaria is a disease characterized by recurrent itchy wheals and/or angioedema lasting longer than 6 weeks. Its pathogenesis is multifactorial, and there are studies showing that interleukin (IL)-31 and IL-33 cytokines play a role in the pathogenesis.

Material and methods
A total of 79 chronic urticaria patients aged between 18 and 65 years who applied to the allergy outpatient clinic between October and December 2020 were included in the study. While 35 patients were given antihistamine treatment alone, 44 patients were given omalizumab in addition to antihistamines. In addition to routine examination of chronic urticaria patients, serum IL-31 and IL-33 levels were studied in patients and healthy volunteers.

Results
The only variable that was found to be statistically significantly higher in chronic urticaria patients compared with the control group was the IL-31 level. There was no significant difference when the groups were compared in terms of the IL-33 level. There was no significant change in IL-31 and IL-33 levels before and after treatment in patients receiving omalizumab treatment.

Conclusions
IL-31 levels were found to be high in chronic urticaria patients receiving antihistamine treatment, independent of omalizumab treatment.

keywords:

Does IL-31 level have more significance in chronic urticaria, when compared with IL-33 level?

Güzin Özden 1 , Didar Yanardag Acık 2 , Asım Tekin 3 , Mehmet Bankir 4 , Leyla Cevirme 5 , Yavuzalp Solak 6

interleukin 31, interleukin 33, chronic urticaria, cytokines, omalizumab

Güzin Özden

¹

,

Didar Yanardag Acık

²

,

Asım Tekin

³

,

Mehmet Bankir

⁴

,

Leyla Cevirme

⁵

,

Yavuzalp Solak

⁶