eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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3/2021
vol. 27
 
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abstract:
Original paper

Early functional and metabolic disorders in children with type I diabetes mellitus and diabetic nephropathy

Ievgeniia Burlaka
1
,
Vitaliy Maidannyk
1

1.
Department of Pediatrics No. 4, Bogomolets National Medical University, Ukraine
Pediatr Endocrinol Diabetes Metab 2021; 27 (3): 170–177
Online publish date: 2021/09/30
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Type 1 diabetes (T1D) is mainly a disease of children and young adults. The onset of disease is associated with 3 classical symptoms: polydipsia, polyphagia, and polyuria. Hyperglycaemia is the main and primary metabolic disorder in T1D. One of the complications developing as a result of microangiopathy is diabetic nephropathy (DN). Additionally, diabetes remains the most common reason for progressing to end-stage renal disease (ESRD).

The aim of the study was to evaluate the most initial metabolic and functional disorders in diabetic children and children with DN.

The study involved 76 children with T1D and diabetic nephropathy (aged 3 to 17 years). The levels of ET-1 measured using ELISA assay and ratio of lipid oxidation measured spectrophotometrically. Main clinical parameters (blood pressure, glycaemia, albuminuria, creatininaemia, HbA1C, cholesterol levels) were measured using conventional methods available in Clinical Paediatric Hospital No. 6 (Kyiv, Ukraine). The glomerular filtration rate (GFR) was calculated using the Schwartz formula. Patterns of the BP changes, kidney function impairment, ET-level, and metabolic and functional disorders in children with T1D and DN were found.
keywords:

diabetes mellitus, diabetic nephropathy, stage progression, ET-1, GFR, metabolic disorders, lipids oxidation



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