Clinical and Experimental Hepatology
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ISSN: 2392-1099
Clinical and Experimental Hepatology
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4/2025
vol. 11
 
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Original paper

Effect and prognostic factors of the double plasma molecular adsorption system combined with partial plasma exchange (DPMAS-PPE) in patients with liver failure

Xudong Liu
1
,
Xiaofang Zhao
1
,
Chunni Liang
1
,
Ruichao Fang
1
,
Yinying Liao
1
,
Qianjun Ren
1
,
Su Li
1
,
Yuqing Cheng
1
,
Xiaozu Meng
1
,
Weiqin Lu
1

  1. Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Clin Exp HEPATOL 2025; 11, 4
Online publish date: 2025/12/15
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1. Li P, Liang X, Xu S, et al. A non-bioartificial liver support system combined with transplantation in HBV-related acute-on-chronic liver failure. Sci Rep 2021; 11: 2975.
2. Karvellas CJ, Subramanian RM. Current evidence for extracorporeal liver support systems in acute liver failure and acute-on-chronic liver failure. Crit Care Clin 2016; 32: 439-451.
3. Lu XB, Xiao L, Zhang YX, et al. Evaluation of efficacy and safety of using molecular adsorbent recirculating system in the treatment of patients with chronic liver failure. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007; 19: 44-46.
4. Rosa-Diez GJ, Joannes-Boyau O. The use of adsorption in extracorporeal liver support: The Double Plasma Molecular Adsorption System (DPMAS). Contrib Nephrol 2023; 200: 210-217.
5. Romero CM, Redman APH, Terry SA, et al. Molecular speciation and aromaticity of biochar-manure: Insights from elemental, stable isotope and solid-state DPMAS 13C NMR analyses.
6. J Environ Manage 2021; 280: 111705.
7. Sarin SK, Kedarisetty CK, Abbas Z, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int 2014; 8: 453-471.
8. Gao RY, Wang M, Liu Q, et al. Hypoxia-inducible factor-2α reprograms liver macrophages to protect against acute liver injury through the production of interleukin-6. Hepatology 2020; 71: 2105-2117.
9. Yuan SF, Liu ZY, Ayi Y, et al. Effects of bone marrow mesenchymal stem cell transplantation on the expression of stromal cell-derived factor-1α and vascular endothelial growth factor in rats with acute hepatic failure. Zhonghua Gan Zang Bing Za Zhi 2018; 26: 750-755.
10. Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure (2018). J Clin Hepatol 2019; 35: 38-44.
11. Benítez C, Arnold J, Cambindo V, et al. Effect of acute on chronic liver failure over post-transplant survival. Ann Hepatol 2023; 28: 101128.
12. Bernal W, Jalan R, Quaglia A, et al. Acute-on-chronic liver failure. Lancet 2015; 386: 1576-1587.
13. Reuben A, Tillman H, Fontana RJ, et al. Outcomes in adults with acute liver failure between 1998 and 2013: An observational cohort study. Ann Intern Med 2016; 164: 724-732.
14. Tingting D, Li L, Ying G, et al. Research progress of evaluating prognosis of HBV-associated chronic and acute liver failure by inflammatory markers. J Clin Hepatobiliary Dis 2022; 38: 2346-2351.
15. Zhou C, Zhang N, He TT, et al. High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure. World J Gastroenterol 2020; 26: 4479-4488.
16. Xiao N, Liu L, Zhang Y, et al. A practical nomogram based on serum interleukin-6 for the prognosis of liver failure. Front Med (Lausanne) 2022; 9: 1035699.
17. Murakami S, Imamura M, Uchida T, et al. Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure. Hepatol Int 2023; 17: 1225-1232.
18. Maeda A, Nagino M, Takeuchi E, et al. Interleukin 6 in bile as an indicator of liver function after hepatectomy in patients with biliary tract carcinoma. Br J Surg 1999; 86: 458-464.
19. Rahi V, Jamwal S, Kumar P. Neuroprotection through G-CSF: recent advances and future viewpoints. Pharmacol Rep 2021; 73: 372-385.
20. Wan Z, You S, Rong Y, et al. CD34+ hematopoietic stem cells mobilization, paralleled with multiple cytokines elevated in patients with HBV-related acute-on-chronic liver failure. Dig Dis Sci 2013; 58: 448-457.
21. Liu Z, Zhang G, Chen J, et al. G-CSF promotes the viability and angiogenesis of injured liver via direct effects on the liver cells. Mol Biol Rep 2022; 49: 8715-8725.
22. Saha BK, Mahtab MA, Akbar SMF, et al. Therapeutic implications of granulocyte colony stimulating factor in patients with acute-on-chronic liver failure: increased survival and containment of liver damage. Hepatol Int 2017; 11: 540-546.
23. Khanam A, Trehanpati N, Garg V, et al. Altered frequencies of dendritic cells and IFN-gamma-secreting T cells with granulocyte colony-stimulating factor (G-CSF) therapy in acute-on- chronic liver failure. Liver Int 2014; 34: 505-513.
24. Engelmann C, Habtesion A, Hassan M, et al. Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF. J Hepatol 2022; 77: 1325-1338.
25. Chen H, Tang S, Liao J, et al. Therapeutic effect of human umbilical cord blood mesenchymal stem cells combined with G-CSF on rats with acute liver failure. Biochem Biophys Res Commun 2019; 517: 670-676.
26. Zhu B, You S, Rong Y, et al. A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure. Braz J Med Biol Res 2020; 53: e9728.
27. De A, Kumari S, Singh A, et al. Multiple cycles of granulocyte colony-stimulating factor increase survival times of patients with decompensated cirrhosis in a randomized trial. Clin Gastroenterol Hepatol 2021; 19: 375-383.
28. Kabbani AR, Tergast TL, Manns MP, et al. Behandlungsstrategien des akut-auf-chronischen Leberversagens [Treatment strategies for acute-on-chronic liver failure]. Med Klin Intensivmed Notfmed 2021; 116: 3-16.
29. Shi P, Zhang J, Wu M, et al. The effects of granulocyte-colony stimulating factor on chronic liver disease: a meta-analysis. J Infect Dev Ctries 2022; 16: 537-546.
30. Colli A, Fraquelli M, Prati D, et al. Granulocyte colony-stimulating factor with or without stem or progenitor cell or growth factors infusion for people with compensated or decompensated advanced chronic liver disease. Cochrane Database Syst Rev 2023; 6: CD013532.
31. Martin-Mateos R, González-Alonso R, Álvarez-Díaz N, et al. Granulocyte-colony stimulating factor in acute-on-chronic liver failure: Systematic review and meta-analysis of randomized controlled trials. Gastroenterol Hepatol 2023; 46: 350-359.
32. Yuan S, Qian Y, Tan D, et al. Therapeutic plasma exchange: A prospective randomized trial to evaluate 2 strategies in patients with liver failure. Transfus Apher Sci 2018; 57: 253-258.
33. Sun L, Fan X, Zhang L, et al. Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats. Int J Mol Med 2014; 34: 987-996.
34. Barreiros AP, Sprinzl M, Rosset S, et al. EGF and HGF levels are increased during active HBV infection and enhance survival signaling through extracellular matrix interactions in primary human hepatocytes. Int J Cancer 2009; 124: 120-129.
35. Piscaglia AC, Arena V, Passalacqua S, et al. A case of granulocyte-colony stimulating factor/plasmapheresis-induced activation of granulocyte-colony stimulating factor-positive hepatic progenitors in acute-on-chronic liver failure. Hepatology 2015; 62: 649-652.
36. Hou X, Li Y, Yuan H, et al. Therapeutic effect and safety of granulocyte colony-stimulating factor therapy for acute-on-chronic liver failure: A systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne) 2021; 8: 784240.
37. Xun YH, Shi JP, Li CQ, et al. Prognostic performance of a series of model for end-stage liver disease and respective scores in patients with hepatitis B acute-on-chronic liver failure. Mol Med Rep 2014; 9: 1559-1568.
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