Abstract
6/2012
vol. 16
Original paper
Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
Wspolczesna Onkol 2012; 16 (6): 512–515
Online publish date: 2013/01/04
Aim of the study: To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro.
Material and methods: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis.
Results: Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King’s formula).
Conclusions: Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
Material and methods: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis.
Results: Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King’s formula).
Conclusions: Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
Keywords
rapamycin, cisplatin, cervical carcinoma, Hela cells
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