Effect of combination of rapamycin and cisplatin on human cervical carcinoma
Hela cells

Lu Han; Jie-Ling Wu; Li-Xiao Yang

doi:10.5114/wo.2012.32483

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2012
vol. 16

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abstract:

Original paper

Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells

Lu Han

,

Jie-Ling Wu

,

Li-Xiao Yang

Wspolczesna Onkol 2012; 16 (6): 512–515

DOI: https://doi.org/10.5114/wo.2012.32483

Online publish date: 2013/01/04

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Aim of the study: To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro.

Material and methods: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis.

Results: Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King’s formula).

Conclusions: Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.

keywords:

Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells

Lu Han , Jie-Ling Wu , Li-Xiao Yang

rapamycin, cisplatin, cervical carcinoma, Hela cells

Lu Han

,

Jie-Ling Wu

,

Li-Xiao Yang