eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2016
vol. 12
 
Share:
Share:
abstract:
Original paper

Effects of erythropoiesis-stimulating agents on heart failure patients with anemia: a meta-analysis

Hengliang Zhang
,
Pei Zhang
,
Yaheng Zhang
,
Junqiang Yan
,
Pingshuan Dong
,
Yanyu Wang
,
Xiaowei Niu

Adv Interv Cardiol 2016; 12, 3 (45): 247–253
Online publish date: 2016/08/19
View full text Get citation
 
Introduction: Heart failure (HF) is always complicated with anemia and is associated with bad prognosis in this patient population. Several studies have assessed the potential role of erythropoietin-stimulating agent (ESA) in improving cardiac function and reducing the number of hospitalizations in anemic patients with HF.

Aim: We performed a meta-analysis to assess the potential role of ESA in the treatment of anemic patients with HF.

Material and methods: A literature and Medline search was performed to identify studies with control groups that examined the efficacy of ESA therapy in patients with HF and anemia.

Results: A total of 11 studies were included (n = 3044 subjects) in the final analysis. Compared to placebo, ESA therapy was associated with increased hemoglobin levels (1.89 g/dl; 95% CI: 1.64–2.14, p < 0.00001), increased left ventricular ejection fraction (LVEF) to 6.88 (95% CI: 0.49–13.28, p = 0.03), decreased B-type natriuretic protein (–272.20; 95% CI: (–444.52)–(–99.89), p = 0.002), improvement in New York Heart Association functional class to –0.33 mean difference (95% CI: (–0.44)–(–0.23), p < 0.00001), and decreased hospitalization (OR = 0.61, 95% CI: 0.39–0.94, p = 0.02). There was no significant between-group difference in all-cause mortality (OR = 0.78, 95% CI: 0.51–1.21, p = 0.27).

Conclusions: The treatment of anemia with ESA therapy did not reduce the rate of all-cause mortality among patients with heart failure, but ESA therapy made a potential important contribution to patients’ symptomatic improvement.
keywords:

meta-analysis, heart failure, randomized controlled trials, anemia, erythropoietin-stimulating agents

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.