Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa

Marcos A. González-López; J. Gonzalo Ocejo-Viñals; Cristina Mata; Diego Díaz; Sandra Guiral; Virginia Portilla; Alfonso Corrales; M. Carmen González-Vela; Miguel A. González-Gay; Ricardo Blanco; José L. Hernández

doi:10.5114/ada.2021.107932

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Evaluation of serum omentin-1 and apelin concentrations in patients with hidradenitis suppurativa

Marcos A. González-López

¹

,

J. Gonzalo Ocejo-Viñals

²

,

Cristina Mata

³

,

Diego Díaz

¹

,

Sandra Guiral

²

,

Virginia Portilla

⁴

,

Alfonso Corrales

⁴

,

M. Carmen González-Vela

⁵

,

Miguel A. González-Gay

⁴

,

Ricardo Blanco

⁴

,

José L. Hernández

⁶

Division of Dermatology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Cantabria, Spain

Division of Immunology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Cantabria, Spain

Division of Rheumatology, Hospital Comarcal, Laredo, Cantabria, Spain

Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Cantabria, Spain

Division of Pathology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Cantabria, Spain

Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Cantabria, Spain

Adv Dermatol Allergol 2021; XXXVIII (3): 450–454

DOI: https://doi.org/10.5114/ada.2021.107932

Online publish date: 2021/07/26

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AMA

A. González-López M, Gonzalo Ocejo-Viñals J, Mata C, et al. Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(3):450-454. doi:10.5114/ada.2021.107932.

APA

A. González-López, M., Gonzalo Ocejo-Viñals, J., Mata, C., Díaz, D., Guiral, S.,  & Portilla, V. et al. (2021). Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(3), 450-454. https://doi.org/10.5114/ada.2021.107932

Chicago

A. González-López, Marcos, J. Gonzalo Ocejo-Viñals, Cristina Mata, Diego Díaz, Sandra Guiral, Virginia Portilla,  and Alfonso Corrales et al. 2021. "Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (3): 450-454. doi:10.5114/ada.2021.107932.

Harvard

A. González-López, M., Gonzalo Ocejo-Viñals, J., Mata, C., Díaz, D., Guiral, S., Portilla, V., Corrales, A., González-Vela, M., A. González-Gay, M., Blanco, R.,  and L. Hernández, J. (2021). Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(3), pp.450-454. https://doi.org/10.5114/ada.2021.107932

MLA

A. González-López, Marcos et al. "Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 3, 2021, pp. 450-454. doi:10.5114/ada.2021.107932.

Vancouver

A. González-López M, Gonzalo Ocejo-Viñals J, Mata C, Díaz D, Guiral S, Portilla V et al. Evaluation of serum omentin-1 and apelin concentrations
in patients with hidradenitis suppurativa. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(3):450-454. doi:10.5114/ada.2021.107932.

Introduction
Recent studies suggest a role of adipokines in the pathogenesis of hidradenitis suppurativa (HS). Omentin-1 and apelin are two recently identified adipokines that have been involved in the regulation of metabolic and inflammatory responses.

Aim
To investigate serum omentin-1 and apelin levels in patients with HS and to assess their associations with metabolic parameters, disease severity and HS risk.

Material and methods
This case-control study included 139 non-diabetic individuals (78 HS patients and 61 ageand sex-matched controls). Serum concentrations of omentin-1 and apelin and the homeostasis model assessment of insulin resistance (HOMA-IR) were measured in all participants.

Results
Serum omentin-1 concentrations were significantly higher in HS patients compared to controls, whereas apelin serum levels did not significantly differ between both groups. These differences in omentin-1 concentrations remained significant even after adjusting for age, sex, and body mass index (BMI). The results of logistic regression analysis showed that increased omentin-1 plasma levels were an independent risk factor for HS. However, we found no association between serum levels of both omentin-1 and apelin with HS severity.

Conclusions
Our results show that patients with HS have raised omentin-1 serum levels, which are associated with HS risk.

keywords:

Evaluation of serum omentin-1 and apelin concentrations in patients with hidradenitis suppurativa

Marcos A. González-López 1 , J. Gonzalo Ocejo-Viñals 2 , Cristina Mata 3 , Diego Díaz 1 , Sandra Guiral 2 , Virginia Portilla 4 , Alfonso Corrales 4 , M. Carmen González-Vela 5 , Miguel A. González-Gay 4 , Ricardo Blanco 4 , José L. Hernández 6

hidradenitis suppurativa, apelin, omentin, adipokines