Pediatric Endocrinology Diabetes and Metabolism

Full text

3/2026 vol. 32
Original paper

Examination of factors affecting adropin levels in healthy and obese children

  1. Child Health and Diseases, Erzurum City Hospital, Turkey

  2. Department of Child Health and Diseases, Division of Paediatric Endocrinology, Faculty of Medicine, Atatürk University, Erzurum, Turkey

  3. Department of Medical Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey

  4. Department of Biostatistics, Faculty of Medicine, Atatürk University, Erzurum, Turkey

  5. Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Turkey

Pediatr Endocrinol Diabetes Metab 2026; 32 (3): 193-200

Data publikacji online: 2026/09/14
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0430_Examination of factors.pdf
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  1. Kumar KG, Trevaskis JL, Lam DD, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab 2008; 8: 468–481. doi: 10.1016/j.cmet.2008.
  2. Shahjouei S, Ansari S, Pourmotabbed T, Zand R. Potential roles of adropin in central nervous system: review of current literature. Front Mol Biosci 2016; 3: 25. doi: 10.3389/fmolb.2016.00025.
  3. Wong CM, Wang Y, Lee JT, et al. Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice. J Biol Chem 2014; 289: 25976–25986. doi: 10.1074/jbc.M114.576058.
  4. Jasaszwili M, Billert M, Strowski MZ, et al. Adropin as a fat-burning hormone with multiple functions-review of a decade of research. Molecules 2020; 25: 549. doi: 10.3390/molecules25030549.
  5. Altincik A, Sayin O. Evaluation of the relationship between serum adropin levels and blood pressure in obese children. J Pediatr Endocrinol Metab 2015; 28: 1095–1100. doi: 10.1515/jpem-2015-0051.
  6. Chang JB, Chu NF, Lin FH, et al. Relationship between plasma adropin levels and body composition and lipid characteristics amongst young adolescents in Taiwan. Obes Res Clin Pract 2018; 12: 101–107. doi: 10.1016/j.orcp.2017.03.001.
  7. Kocaoglu C, Buyukinan M, Erdem SS, Ozel A. Are obesity and metabolic syndrome associated with plasma adropin levels in children? J Pediatr Endocrinol Metab 2015; 28: 1293–1297. doi: 10.1515/jpem-2015-0117.
  8. Zhang H, Jiang L, Yang YJ, et al. Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss. Sci Rep 2017; 7: 17717. doi: 10.1038/s41598-017-18086-3.
  9. Sayın O, Tokgöz Y, Arslan N. Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2014; 27: 479–484. doi: 10.1515/jpem-2013-0296.
  10. Gokdemir I, Bezen D, Dikker O, et al. Evaluation of the relationship between adropin levels and blood pressure in obese adolescents. Inn J Pediatr 2023; 33: e139957. doi: 10.5812/ijp-139957
  11. Bays JA, Bartlett AM, Boone AM, et al. Serum adropin is unaltered in adolescents with histology-confirmed steatotic liver disease. J Pediatr Gastroenterol Nutr 2024; 80: 182–188. doi: 10.1002/jpn3.12423.
  12. Herrero L, de Dios O, Gavela-Pérez T, et al. Opposite association of adropin concentrations with obesity in prepubertal children compared with adolescents. Obesity (Silver Spring) 2020; 28: 17361741. doi: 10.1002/oby.22886.
  13. Hasanpour-Segherlou Z, Butler AA, Candelario-Jalil E, Hoh BL. Role of the unique secreted peptide adropin in various physiological and disease states. Biomolecules 2024; 14: 1613. doi: 10.3390/biom14121613.
  14. Demir K, Özen S, Konakçı E, et al. A comprehensive online calculator for pediatric endocrinologists: ÇEDD Çözüm/TPEDS Metrics. J Clin Res Pediatr Endocrinol 2017; 9: 182184. doi: 10.4274/jcrpe.4526.
  15. Strauss RS. Childhood obesity. Pediatr Clin North Am 2002; 49: 175201 doi: 10.1016/s0031-3955(03)00114-7.
  16. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 1323. doi: 10.1136/adc.45.239.13.
  17. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291303. doi: 10.1136/adc.44.235.291.
  18. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419. doi: 10.1007/BF00280883.
  19. Yuan X, Chen R, Ouyang Q, et al. Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity. J Pediatr Endocrinol Metab 2020; 33: 265–270. doi: 10.1515/jpem-2019-0329.
  20. Yin C, Zhang H, Zhang M, Xiao Y. Adropin and apelin-12 efficiently predict metabolic syndrome in obese children. Pediatric diabetes 2020; 21: 1132–1139. doi: 10.1111/pedi.13101.
  21. Han W, Zhang C, Wang H, et al. Alterations of irisin, adropin, preptin and BDNF concentrations in coronary heart disease patients comorbid with depression. Ann Transl Med 2019; 7: 298. doi: 10.21037/atm.2019.05.77.
  22. Butler AA, Tam CS, Stanhope KL, et al. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J Clin Endocrinol Metab 2012; 97: 3783–3791. doi: 10.1210/jc.2012–2194.
  23. Kumar KG, Zhang J, Gao S, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity (Silver Spring) 2012; 20: 13941402. doi: 10.1038/oby.2012.31.
  24. Majeed AA, Al-Qaisi AHJ, Ahmed WA. The comparison of irisin, subfatin, and adropin in normal-weight and obese polycystic ovary syndrome patients. Iran J Med Sci 2024; 49: 350358. doi: 10.30476/ijms.2023.99130.3117.
  25. Rooban S, Arul Senghor KA, Vinodhini VM, Kumar JS. Adropin: a crucial regulator of cardiovascular health and metabolic balance. Metabol Open 2024; 23: 100299. doi: 10.1016/j.metop.2024.100299.
  26. Alzoughool F, Abdelqader R, Abumweis S, et al. Evaluation of adropin level and insulin resistance in non-alcoholic fatty liver patients: a meta-analysis of studies. Eur Rev Med Pharmacol Sci 2024; 28: 45074514. doi: 10.26355/eurrev_202411_36909.
  27. Aydin HI, Eser A, Kaygusuz I, et al. Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers. J Perinat Med 2016; 44: 669676. doi: 10.1515/jpm-2014-0353.
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