Expression of C-terminal tensin-like in breast
carcinoma and its correlation with known
prognostic factors

Usma Arshad; Syeda Fatima Rizvi; Shahzada Khalid Sohail; Samina Qamar; Rahat Sarfraz; Maham Akhlaq

doi:10.5114/pjp.2025.149282

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2025
vol. 76

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abstract:

Original paper

Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors

Usma Arshad

¹

,

Syeda Fatima Rizvi

²

,

Shahzada Khalid Sohail

²

,

Samina Qamar

¹

,

Rahat Sarfraz

¹

,

Maham Akhlaq

¹

Department of Pathology, King Edward Medical University Lahore, Pakistan
Department of Pathology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia

Pol J Pathol 2025; 76 (1): 10-15

DOI: https://doi.org/10.5114/pjp.2025.149282

Online publish date: 2025/05/10

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C-terminal tensin-like (Cten) is a marker for poorly differentiated breast cancer. We evaluated the immunohistochemical expression of Cten in invasive breast carcinoma in our population and correlated it with known histopathologic prognostic variables.

Fifty-seven specimens of modified radical mastectomy diagnosed as invasive ductal carcinoma were collected. The histopathologic findings were noted independent of the result of Cten. According to the results of Cten immunohistochemistry, the tumors were categorized as negative/mild, moderate, or high expression and were statistically corelated with histologic findings.

In our study, 47 (82.5%) cases showed negative/mild expression, 2 (3.5%) cases showed moderate staining, and 8 (14%) cases showed strong expression of Cten.

Positive Cten was present in pT4 stage tumors. Similarly, grade III tumor showed moderate expression in 2 (3.5%) cases and strong staining in 8 (14%) cases. Posi-tive expression of Cten was observed in cases with lymphovascular invasion (LVI) and high axillary lymph nodal involvement (N3). All these poor prognostic factors were significantly associated with moderate to high expression of Cten.

We found that tumor size and extent, histologic grade, LVI, and lymph node status were significantly associated with Cten expression. C-terminal tensin-like can be used as marker of poor prognosis in breast carcinoma.

keywords:

Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors

Usma Arshad 1 , Syeda Fatima Rizvi 2 , Shahzada Khalid Sohail 2 , Samina Qamar 1 , Rahat Sarfraz 1 , Maham Akhlaq 1

breast carcinoma, Cten, immunohistochemistry, lymphovascular invasion, pathological stage

Usma Arshad

¹

,

Syeda Fatima Rizvi

²

,

Shahzada Khalid Sohail

²

,

Samina Qamar

¹

,

Rahat Sarfraz

¹

,

Maham Akhlaq

¹