eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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3/2013
vol. 17
 
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abstract:
Original paper

Expression of β-catenin and AXIN2 in ameloblastomas

Zhenhui Wei
,
Ming Zhong
,
Yan Guo
,
Yan Wang
,
Meisi Ren
,
Zhaoyuan Wang

Wspolczesna Onkol 2013; 17 (3): 250–256
Online publish date: 2013/06/28
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Aim of the study: To investigate the ex­pression status and association of β-ca­tenin and AXIN2 in ameloblastoma.

Material and methods: 30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of

β-ca­tenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis. The relationship between β-catenin and AXIN2 protein and clinico-pathological parameters and prognosis was subsequently determined.

Results: The results show that β-catenin mRNA expression was 1.24-fold higher in ameloblastomas than that in normal mucosa tissues, but AXIN2 mRNA expression was 0.47-fold lower in ameloblastomas than that in normal mucosa tissues (p < 0.05). The Western blot results show that β-catenin and AXIN2 protein in ameloblastomas had a significantly higher level than normal mucosa tissues

(p < 0.05). Immunohistochemical staining of β-catenin and AXIN2 protein in ame­loblastoma was expressed at a higher level than normal oral mucosa (p < 0.05).

Conclusions: AXIN2 and β-catenin play an important role in the tumorigenesis and progression of ameloblastoma.
keywords:

ameloblastoma, β-catenin, AXIN2, Wnt pathway

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