eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2016
vol. 67
 
Share:
Share:
more
 
 
abstract:
Original paper

Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma

Piotr Czapiewski
,
Adam Gorczyński
,
Johannes Haybaeck
,
Krzysztof Okoń
,
Joanna Reszeć
,
Wojciech Skrzypczak
,
Jarosław Dzierżanowski
,
Michał Kunc
,
Joanna Karczewska
,
Wojciech Biernat

Pol J Pathol 2016; 67 (2): 130-135
Online publish date: 2016/08/02
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs.

We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated.

TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis.

No significant correlation in the expression of PAX5 and TTF-1 ( = 0.43; p = 0.18) was observed.

ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive.

PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course.
keywords:

olfactory neuroblastoma, esthesioneuroblastoma, ISL-1, TTF-1, PAX5

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.