Abstract
Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters
- Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria
- Department of the Living and Environment, University of Sciences and Technology of Oran, Mohammed-Boudiaf, Oran, Algeria
- University Ain Temouchent Belhadj Bouchaib, Ain Temouchent, Algeria
- Department of Medical Oncology, University Hospital Establishment of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria
- Faculty of Medicine, Abdelhamid Ben Badis University Mostaganem, Mostaganem, Algeria
- Immunology Laboratory, Pasteur Institute of Oran, Oran, Algeria
- Department of Gynaecology and Obstetrics, University Hospital Establishment of Oran, Oran, Algeria
- Department of Epidemiology and Preventive Medicine, University Hospital of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria
Introduction:
Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease. The aim of this study was to evaluate the concentrations of these molecules and to find a possible correlation with the clinicopathological parameters of patients with BC from western Algeria.
Material and methods:
We evaluated the serum levels of IL-6, 4-HNE, and HIF-1α by ELISA technique and compare them in different age groups and BC molecular subtypes, and then correlated them with clinicopathological parameters.
Results:
Our study revealed a significant increase in 4-HNE (p < 0.05), and a negative correlation (p < 0.05) was found between IL-6 serum levels and lymph node count, but not (p > 0.05) between 4-HNE, HIF-1α and lymph node count. No significant correlation (p > 0.05) was found between IL-6, 4-HNE, HIF-1α , and Scarff-Bloom-Richardson grade. Furthermore, there was no significant difference (p > 0.05) in serum levels of IL-6, 4-HNE, and HIF-1α in the different age groups and molecular subtypes of BC.
Conclusions:
The data obtained show that the presence of lipid peroxidation (4-HNE) is a marker of oxidative stress, and that IL-6 is a good prognostic factor due to its negative effect on the number of lymph nodes. Furthermore, age and BC molecular subtypes do not influence the serum concentrations of IL-6,4-HNE, and HIF-1α.
Keywords
breast cancer, interleukin-6, 4-hydroxy-2-nonenal, hypoxia inducible factor 1-α, Scarff-Bloom-Richardson grade
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