Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Saddek Yahia; Zineb Tahari; Asmahane Medjdoub; Fatima Zohra Tahari; Nadia Bessaih; Moussa Messatfa; Fatiha Deblaoui; Mourad Raiah; Houria Ouldcadi; Sonia Seddiki; Tewfik Sahraoui

doi:10.5114/wo.2023.127199

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

Original paper

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Saddek Yahia

¹

,

Zineb Tahari

^{1, 2}

,

Asmahane Medjdoub

^{1, 2}

,

Fatima Zohra Tahari

^{1, 3}

,

Nadia Bessaih

⁴

,

Moussa Messatfa

^{5, 6}

,

Fatiha Deblaoui

⁷

,

Mourad Raiah

⁸

,

Houria Ouldcadi

¹

,

Sonia Seddiki

¹

,

Tewfik Sahraoui

¹

Biology of Development and Differentiation Laboratory, Ahmed Ben Bella Oran 1 University, Oran, Algeria
Department of the Living and Environment, University of Sciences and Technology of Oran, Mohammed-Boudiaf, Oran, Algeria
University Ain Temouchent Belhadj Bouchaib, Ain Temouchent, Algeria
Department of Medical Oncology, University Hospital Establishment of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria
Faculty of Medicine, Abdelhamid Ben Badis University Mostaganem, Mostaganem, Algeria
Immunology Laboratory, Pasteur Institute of Oran, Oran, Algeria
Department of Gynaecology and Obstetrics, University Hospital Establishment of Oran, Oran, Algeria
Department of Epidemiology and Preventive Medicine, University Hospital of Oran, Faculty of Medicine, Ahmed Ben Bella Oran 1 University, Oran, Algeria

Contemp Oncol (Pozn) 2023; 27 (1): 14–21

DOI: https://doi.org/10.5114/wo.2023.127199

Online publish date: 2023/04/27

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AMA

Yahia S, Tahari Z, Medjdoub A, et al. Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters. Contemporary Oncology/Współczesna Onkologia. 2023;27(1):14-21. doi:10.5114/wo.2023.127199.

APA

Yahia, S., Tahari, Z., Medjdoub, A., Tahari, F., Bessaih, N.,  & Messatfa, M. et al. (2023). Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters. Contemporary Oncology/Współczesna Onkologia, 27(1), 14-21. https://doi.org/10.5114/wo.2023.127199

Chicago

Yahia, Saddek, Zineb Tahari, Asmahane Medjdoub, Fatima Zohra Tahari, Nadia Bessaih, Moussa Messatfa,  and Fatiha Deblaoui et al. 2023. "Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters". Contemporary Oncology/Współczesna Onkologia 27 (1): 14-21. doi:10.5114/wo.2023.127199.

Harvard

Yahia, S., Tahari, Z., Medjdoub, A., Tahari, F., Bessaih, N., Messatfa, M., Deblaoui, F., Raiah, M., Ouldcadi, H., Seddiki, S.,  and Sahraoui, T. (2023). Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters. Contemporary Oncology/Współczesna Onkologia, 27(1), pp.14-21. https://doi.org/10.5114/wo.2023.127199

MLA

Yahia, Saddek et al. "Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters." Contemporary Oncology/Współczesna Onkologia, vol. 27, no. 1, 2023, pp. 14-21. doi:10.5114/wo.2023.127199.

Vancouver

Yahia S, Tahari Z, Medjdoub A, Tahari F, Bessaih N, Messatfa M et al. Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters. Contemporary Oncology/Współczesna Onkologia. 2023;27(1):14-21. doi:10.5114/wo.2023.127199.

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Introduction:
Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease. The aim of this study was to evaluate the concentrations of these molecules and to find a possible correlation with the clinicopathological parameters of patients with BC from western Algeria.

Material and methods:
We evaluated the serum levels of IL-6, 4-HNE, and HIF-1α by ELISA technique and compare them in different age groups and BC molecular subtypes, and then correlated them with clinicopathological parameters.

Results:
Our study revealed a significant increase in 4-HNE (p < 0.05), and a negative correlation (p < 0.05) was found between IL-6 serum levels and lymph node count, but not (p > 0.05) between 4-HNE, HIF-1α and lymph node count. No significant correlation (p > 0.05) was found between IL-6, 4-HNE, HIF-1α , and Scarff-Bloom-Richardson grade. Furthermore, there was no significant difference (p > 0.05) in serum levels of IL-6, 4-HNE, and HIF-1α in the different age groups and molecular subtypes of BC.

Conclusions:
The data obtained show that the presence of lipid peroxidation (4-HNE) is a marker of oxidative stress, and that IL-6 is a good prognostic factor due to its negative effect on the number of lymph nodes. Furthermore, age and BC molecular subtypes do not influence the serum concentrations of IL-6,4-HNE, and HIF-1α.

keywords:

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

Saddek Yahia 1 , Zineb Tahari 1, 2 , Asmahane Medjdoub 1, 2 , Fatima Zohra Tahari 1, 3 , Nadia Bessaih 4 , Moussa Messatfa 5, 6 , Fatiha Deblaoui 7 , Mourad Raiah 8 , Houria Ouldcadi 1 , Sonia Seddiki 1 , Tewfik Sahraoui 1

breast cancer, interleukin-6, 4-hydroxy-2-nonenal, hypoxia inducible factor 1-α, Scarff-Bloom-Richardson grade

Saddek Yahia

¹

,

Zineb Tahari

^{1, 2}

,

Asmahane Medjdoub

^{1, 2}

,

Fatima Zohra Tahari

^{1, 3}

,

Nadia Bessaih

⁴

,

Moussa Messatfa

^{5, 6}

,

Fatiha Deblaoui

⁷

,

Mourad Raiah

⁸

,

Houria Ouldcadi

¹

,

Sonia Seddiki

¹

,

Tewfik Sahraoui

¹