Abstract
FIB-5 versus FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients
- Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Egypt
- Community and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt
- Pathology Department, National Liver Institute, Menoufia University, Egypt
Aim of the study
Chronic hepatitis B virus (HBV) infection is one of the major health problems worldwide. Use of non-invasive tests for assessment of hepatic fibrosis such as the FIB-4 index could be used to avoid liver biopsy. Another promising noninvasive test, FIB-5, could also be used to detect significant hepatic fibrosis. The aim of the study was to compare the use of FIB-5 and FIB-4 as noninvasive markers to assess chronic HBV-related hepatic fibrosis.
Material and methods
This study was done on 176 chronic HBV patients who underwent liver biopsy. Grading and staging of liver fibrosis was done according to the METAVIR scoring system. FIB-5 and FIB-4 scores were calculated for all patients.
Results
As regards FIB-4 for differentiation between non-significant fibrosis (group I) and significant fibrosis (group II), at a cutoff level of 1.28 with positive predictive value (PPV) 41.4% and specificity 48% while at a cutoff level of 7.08 with PPV 98.8% and specificity 98% for FIB-5.
Conclusions
As regards both scores, the FIB-5 score was more specific than FIB-4 for diagnosing significant from nonsignificant hepatic fibrosis in patients with chronic HBV infection.
Keywords
FIB-5, FIB-4, fibrosis, biopsy, chronic HBV
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