eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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2/2007
vol. 45
 
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abstract:

Felty’s syndrome and T-cell large granular lymphocyte leukaemia – similarities and differences

Monika Prochorec-Sobieszek
,
Teresa Wagner
,
Renata K. Maryniak

Reumatologia 2007; 45, 2: 85–91
Online publish date: 2007/04/25
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Recent studies suggest that Felty’s syndrome (FS) and T-cell large granular lymphocyte leukaemia (T-LGL) are related disorders that appear to share some pathogenetic mechanisms and clinical features: T-cell large granular lymphocytosis, immune-mediated neutrophil destruction resulting in neutropenia, variable splenomegaly and arthritis. FS is characterized by severe articular and extra-articular manifestations of rheumatoid arthritis (RA), neutropenia and splenomegaly, and in 30% of patients FS is associated with T-cell large granular lymphocytosis. On the other hand, T-LGL presents with monoclonal infiltration of T large granular lymphocytes in the bone marrow and spleen, neutropenia and splenomegaly, and in 25-35% patients it is associated with RA. The article reviews pathogenetic, histopathological, immunogenetic and clinical relations between these two diseases.
keywords:

Felty’s syndrome, T-cell large granular lymphocyte leukaemia







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