Genetic determination of pancreatic cancer

Stanisław Głuszek; Dorota Kozieł

doi:10.5114/ms.2018.76879

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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2/2018
vol. 34

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abstract:

Review paper

Genetic determination of pancreatic cancer

Stanisław Głuszek

,

Dorota Kozieł

Medical Studies/Studia Medyczne 2018; 34 (2): 178–182

DOI: https://doi.org/10.5114/ms.2018.76879

Online publish date: 2018/06/30

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In Poland, malignant pancreatic cancer constitutes approximately 2% of the total number of cancer cases. The prognoses are very unfavourable, compared to other serious cancerous diseases of the gastrointestinal tract. Pancreatic cancer is a disease about which little is known concerning the etiopathogenesis and risk factors. The presented study demonstrates the role of the best recognised genetic mutations in the development of pancreatic cancer. The objective of the review of literature is the analysis of selected genetic risk factors of pancreatic cancer: BRCA1, BRCA2, PALB2, and STK11. The role of genetic mutations in the development of pancreatic cancer remains unclear. To-date, no gene has been discovered the damage of which is specifically related with cancer of this organ. Multi-centre studies allowing analysis of a large group of patients are a chance for better recognition of the genetic relationships

keywords:

Genetic determination of pancreatic cancer

Stanisław Głuszek , Dorota Kozieł

pancreatic cancer, hereditary mutations, BRCA gene, PALB2 gene, STK11 gene

Stanisław Głuszek

,

Dorota Kozieł