Contemporary Oncology
eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Case report

Glioblastoma with an uncommon TP53 mutation presenting with pleural metastasis: a case report and literature review

Zuzanna Biegała
1
,
Oliwia Kowalczyk
1
,
Julia Sołek
1
,
Piotr Czapiewski
2, 3
,
Jakub Jankowski
4
,
Maciej Radek
4
,
Dominik Paprocki
1
,
Witold Skierkowski
1
,
Marcin Braun
1

  1. Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
  2. Department of Pathology, Staedtisches/Städtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane, Dessau, Germany
  3. Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
  4. Clinic of Neurosurgery, Spine Surgery and Peripheral Nerve Surgery, Medical University of Lodz, Lodz, Poland
Contemp Oncol (Pozn) 2025; 30 (1)
Online publish date: 2026/02/23
Article file
- Glioblastoma with.pdf  [2.65 MB]
Get citation
 
PlumX metrics:
 
1. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 2021; 23: 1231-1251.
2. Rosen J, Blau T, Grau SJ, Barbe MT, Fink GR, Galldiks N. Extracranial metastases of a cerebral glioblastoma: a case report and review of the literature. Case Rep Oncol 2018; 11: 591-600.
3. Liu J, Shen L, Tang G, Tang S, Kuang W, Li H, et al. Multiple extracranial metastases from glioblastoma multiforme: a case report and literature review. J Int Med Res 2020; 48: 0300060520930459.
4. Andaloussi-Saghir K, Oukabli M, El Marjany M, Sifat H, Hadadi K, Mansouri H. Secondary gliosarcoma after the treatment of primary glioblastoma multiforme. North Am J Med Sci 2011; 3: 527-530.
5. Kumaria A, Teale A, Kulkarni GV, Ingale HA, Macarthur DC, Robertson IJA. Glioblastoma multiforme metastatic to lung in the absence of intracranial recurrence: case report. Br J Neurosurg 2022; 36: 290-292.
6. Armstrong TS, Prabhu S, Aldape K, Hossan B, Kang S, Childress A, et al. A case of soft tissue metastasis from glioblastoma and review of the literature. J Neurooncol 2011; 103: 167-172.
7. Undabeitia J, Castle M, Arrazola M, Pendleton C, Ruiz I, Úrculo E. Multiple extraneural metastasis of glioblastoma multiforme. An Sist Sanit Navar 2015; 38: 157-161.
8. Gotway MB, Conomos PJ, Bremner RM. Pleural metastatic disease from glioblastoma multiforme. J Thorac Imaging 2011; 26: W54-W58.
9. Pansera F, Pansera E. An explanation for the rarity of extraaxial metastases in brain tumors. Med Hypotheses 1992; 39: 88-89.
10. Langley RR, Fidler IJ. The seed and soil hypothesis revisited – the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 2011; 128: 2527-2535.
11. Swinnen J, Gelin G, Fransis S, Vandevenne J, Van Cauter S. Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report. Radiol Case Rep 2019; 14: 1334-1347.
12. Hamilton JD, Rapp M, Schneiderhan TM, Sabel M, Hayman A, Scherer A, et al. Glioblastoma multiforme metastasis outside the CNS: three case reports and possible mechanisms of escape. J Clin Oncol 2014; 32: e80-e84.
13. Kim W, Yoo H, Shin SH, Gwak HS, Lee SH. Extraneural metastases of glioblastoma without simultaneous central nervous system recurrence. Brain Tumor Res Treat 2014; 2: 124.
14. Luo M, Yang J, Sun J, Wang F, Chai X. Primary gliosarcoma with widespread extracranial metastases – spatiotemporal morphological variation. Chin Neurosurg J 2022; 8: 20.
15. Mujic A, Hunn A, Taylor AB, Lowenthal RM. Extracranial metastases of a glioblastoma multiforme to the pleura, small bowel and pancreas. J Clin Neurosci 2006; 13: 677-681.
16. Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD. Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 1995; 83: 308-315.
17. Pardo J, Murcia M, García F, Alvarado A. Gliosarcoma: A rare primary CNS tumor. Presentation of two cases. Rep Pract Oncol Radiother 2010; 15: 98-102.
18. Choi MG, Lee JH, Lee MS, Suh SJ, Lee YS, Kang DG. Primary gliosarcoma with extracranial metastasis. Brain Tumor Res Treat 2020; 8: 53.
19. Pain M, Wang H, Lee E, Strahl M, Hamou W, Sebra R, Zhu J, Yong RL. Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma. Oncotarget 2017; 9: 2603-2621.
20. The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455: 1061-1068.
21. Guidi M, Giunti L, Lucchesi M, Scoccianti S, Giglio S, Favre C, et al. Brain tumors in Li-Fraumeni syndrome: a commentary and a case of a gliosarcoma patient. Future Oncol 2017; 13: 9-12.
22. Gonzalez KD, Buzin CH, Noltner KA, Gu D, Li W, Malkin D, et al. High frequency of de novo mutations in Li-Fraumeni syndrome. J Med Genet 2009; 46: 689-693.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
RG
Quick links
© 2026 Termedia Sp. z o.o.
Developed by Termedia.