Abstract
5/2003
vol. 11
Immunological evaluations of women with recurrent pregnancy loss
Gin Prakt 2003, 11, 5, 2-4
Online publish date: 2003/11/12
Recurrent miscarriage abortion (RMA), recurrent pregnancy loss (RPL), recurrent spontaneous abortion (RSA), defined as three or more consecutive pregnancy losses before 22 weeks of gestation, affects 0.5–2% of the pregnant.
Half of cases of RMA can be explained by genetic, hormonal, and anatomical factors. Immunologic factors are believed to be the basis of these idiopathic recurrent miscarriages. Normal pregnancy is associated with dominance of T-helper 2 type responses, whereas pregnancy failure is associated with T-helper 1 type responses. Some studies have shown increased production of pro-inflammatory cytokines (TNF-alfa and interferon-gamma) and reduced production of anti-inflammatory cytokines(IL-10). Most RMA are thought to concern normal embryos and loss could be prevented by an immunological treatment in 75–95% of cases, especially if the woman is below 40 years of age.
Half of cases of RMA can be explained by genetic, hormonal, and anatomical factors. Immunologic factors are believed to be the basis of these idiopathic recurrent miscarriages. Normal pregnancy is associated with dominance of T-helper 2 type responses, whereas pregnancy failure is associated with T-helper 1 type responses. Some studies have shown increased production of pro-inflammatory cytokines (TNF-alfa and interferon-gamma) and reduced production of anti-inflammatory cytokines(IL-10). Most RMA are thought to concern normal embryos and loss could be prevented by an immunological treatment in 75–95% of cases, especially if the woman is below 40 years of age.
Keywords
Recurrent pregnancy loss (RPL), ICAM-1
Integrated with
