Pediatric Endocrinology Diabetes and Metabolism

Implications of adipocyte dysfunction in pediatric obesity: a narrative review

Isabela Sallati 1
,
Sanna Cristina Barbosa de Sousa 2
,
Giovanna Degasperi 3

  1. Undergraduate Student – Faculty of Medicine, Pontifical Catholic University of Campinas, Brazil

  2. Graduate Student – Post-Graduation Program in Health Sciences, Pontifical Catholic University
    of Campinas, Brazil

  3. Professor and Researcher – Post-Graduation Program in Health Sciences, Pontifical Catholic University of Campinas, Brazil

Pediatr Endocrinol Diabetes Metab 2026; 32 (2):

DOI: https://doi.org/10.5114/pedm.2026.161340
Data publikacji online: 2026/06/05
Article file
0424_Implications of adipocyte.pdf
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
  1. Esteve Ràfols M. Adipose tissue: cell heterogeneity and functional diversity. Endocr Nutr 2014; 61: 100–112. doi: 10.1016/j.endonu.2013.03.011.
  2. Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996; 87: 377–389. doi: 10.1016/s0092-8674(00)81359-8.
  3. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008; 453: 783–787. doi: 10.1038/nature06902.
  4. Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 2010; 11: 11–18. doi: 10.1111/j.1467-789X.2009.00623.x.
  5. Lobstein T, Jackson-Leach R, Moodie ML, et al. Child and adolescent obesity: part of a bigger picture. Lancet 2015; 385: 2510–2520. doi: 10.1016/S0140-6736(14)61746-3.
  6. Larqué E, Labayen I, Flodmark CE, et al. From conception to infancy – early risk factors for childhood obesity. Nat Rev Endocrinol 2019; 15: 456–478. doi: 10.1038/s41574-019-0219-1.
  7. Woolford SJ, Sidell M, Li X, et al. Changes in body mass index among children and adolescents during the COVID-19 pandemic. JAMA 2021; 326: 1434–1436. doi: 10.1001/jama.2021.15036.
  8. Kolb H. Obese visceral fat tissue inflammation: from protective to detrimental? BMC Med 2022; 20: 494. doi: 10.1186/s12916-022-02672-y.
  9. Marcus C, Danielsson P, Hagman E. Pediatric obesity – long-term consequences and effect of weight loss. J Intern Med 2022; 292: 870–891. doi: 10.1111/joim.13547.
  10. Fernandes Q, Inchakalody VP, Bedhiafi T, et al. Chronic inflammation and cancer: the two sides of a coin. Life Sci 2024; 338: 122390. doi: 10.1016/j.lfs.2023.122390.
  11. Miracle CE, McCallister CL, Egleton RD, Salisbury TB. Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer. Biochem Biophys Res Commun 2024; 12: 150437. doi: 10.1038/s41392-021-00658-5.
  12. Jebeile H, Kelly AS, O’Malley G, Baur LA. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol 2022; 10: 351–365. doi: 10.1016/S2213-8587(22)00047-X.
  13. Lobstein T, Brinsden H. Atlas of childhood obesity. World Obesity Federation 2019. Available at: https://data.worldobesity.org/resources/11996-Childhood-Obesity-Atlas-Report-ART-V2.pdf (accessed 20 May 2024).
  14. Gurnani M, Birken C, Hamilton J. Childhood obesity: causes, consequences, and management. Pediatr Clin North Am 2015; 62: 821–840. doi: 10.1016/j.pcl.2015.04.001.
  15. Adab P, Pallan M, Whincup PH. Is BMI the best measure of obesity? BMJ 2018; 360: k1274. doi: 10.1136/bmj.k1274.
  16. World Health Organization. Obesity and overweight 2024. Available at: https://www.knowledge-action-portal.com/en/content/obesity-and-overweight (accessed 20 May 2024).
  17. Jayawardene W, Dickinson S, Lohrmann D, Agley J. Arm circumference-to-height ratio as a situational alternative to BMI percentile in assessing obesity and cardiometabolic risk in adolescents. J Obes 2018; 2018: 7456461. doi: 10.1155/2018/7456461.
  18. Sisay BG, Hassen HY, Jima BR, et al. The performance of mid-upper arm circumference for identifying children and adolescents with overweight and obesity: a systematic review and meta-analysis. Public Health Nutr 2022; 25: 607–616. doi: 10.1017/S1368980022000143.
  19. Dobashi K. Evaluation of obesity in school-age children. J Atheroscler Thromb 2016; 23: 32–38. doi: 10.5551/jat.29397.
  20. Shepherd JA, Ng BK, Sommer MJ, Heymsfield SB. Body composition by DXA. Bone 2017; 104: 101–105. doi: 10.1016/j.bone.2017.06.010.
  21. Chula de Castro JA, Lima TR, Silva DAS. Body composition estimation in children and adolescents by bioelectrical impedance analysis: a systematic review. J Body Mov Ther 2018; 22: 134–146. doi: 10.1016/j.jbmt.2017.04.010.
  22. Ly KV, Armstrong T, Yeh J, et al. Free-breathing magnetic resonance imaging assessment of body composition in healthy and overweight children: an observational study. J Pediatr Gastroenterol Nutr 2019; 68: 782–787. doi: 10.1097/MPG.0000000000002309.
  23. Andersson J, Roswall J, Kjellberg E, et al. MRI estimates of brown adipose tissue in children – associations to adiposity, osteocalcin, and thigh muscle volume. Magn Reson Imaging 2019; 58: 135–142. doi: 10.1016/j.mri.2019.02.001.
  24. Voerman E, Santos S, Patro Golab B, et al. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: an individual participant data meta-analysis. PLoS Med 2019; 16: e1002744. doi: 10.1371/journal.pmed.1002744.
  25. McIntyre HD, Catalano P, Zhang C, et al. Gestational diabetes mellitus. Nat Rev Dis Primers 2019; 5: 47. doi: 10.1038/s41572-019-0098-8.
  26. Lecoutre S, Maqdasy S, Lambert M, Breton C. The impact of maternal obesity on adipose progenitor cells. Biomedicines 2023; 11: 3252. doi: 10.3390/biomedicines11123252.
  27. Liang X, Yang Q, Fu X, et al. Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. J Physiol 2016; 594: 4453–4466. doi: 10.1113/JP272123.
  28. Murabayashi N, Sugiyama T, Zhang L, et al. Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue. Eur J Obstet Gynecol Reprod Biol 2013; 169: 39–44. doi: 10.1016/j.ejogrb.2013.02.003.
  29. De Almeida Faria J, Duque-Guimarães D, Carpenter AA, et al. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. Sci Rep 2017; 7: 44949. doi: 10.1038/srep44949.
  30. Kral JG, Biron S, Simard S, et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 2006; 118: e1644–e1649. doi: 10.1542/peds.2006-1379.
  31. Gepstein V, Weiss R. Obesity as the main risk factor for metabolic syndrome in children. Front Endocrinol 2019; 10: 568. doi: 10.3389/fendo.2019.00568.
  32. Eslam M, Alkhouri N, Vajro P, et al. Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement. Lancet Gastroenterol Hepatol 2021; 6: 864–873. doi: 10.1016/S2468-1253(21)00183-7.
  33. Parlee SD, MacDougald OA. Maternal nutrition and risk of obesity in offspring: the Trojan horse of developmental plasticity. Biochim Biophys Acta 2014; 1842: 495–506. doi: 10.1016/j.bbadis.2013.07.007.
  34. Mohammadian Khonsari N, Shahrestanaki E, Ehsani A, et al. Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 2023; 14: 1069164. doi: 10.3389/fendo.2023.1069164.
  35. Stacy SL, Buchanich JM, Ma ZQ, et al. Maternal obesity, birth size, and risk of childhood cancer development. Am J Epidemiol 2019; 188: 1503–1511. doi: 10.1093/aje/kwz118.
  36. Marley AR, Ryder JR, Turcotte LM, Spector LG. Maternal obesity and acute lymphoblastic leukemia risk in offspring: a summary of trends, epidemiological evidence, and possible biological mechanisms. Leuk Res 2022; 121: 106924. doi: 10.1016/j.leukres.2022.106924.
  37. Liu J, Kharazmi E, Liang Q, et al. Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring. Leukemia 2025; 39: 590–598. doi: 10.1038/s41375-025-02517-6.
  38. Caughey RW, Michels KB. Birth weight and childhood leukemia: a meta-analysis and review of the current evidence. Int J Cancer 2009; 124: 2658–2670. doi: 10.1002/ijc.24225.
  39. Milne E, Royle JA, de Klerk NH, et al. Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case-control study. Am J Epidemiol 2009; 170: 221–228. doi: 10.1093/aje/kwp117.
  40. Tsilingiris D, Vallianou NG, Spyrou N, et al. Obesity and leukemia: biological mechanisms, perspectives, and challenges. Curr Obes Rep 2024; 13: 1–34. doi: 10.1007/s13679-023-00542-z.
  41. Zhou W, Chen X, Huang H, et al. Birth weight and incidence of breast cancer: dose-response meta-analysis of prospective studies. Clin Breast Cancer 2020; 20: 555–568. doi: 10.1016/j.clbc.2020.04.011.
  42. Lahmann PH, Gullberg B, Olsson H, et al. Birth weight is associated with postmenopausal breast cancer risk in Swedish women. Br J Cancer 2004; 91: 1666–1668. doi: 10.1038/sj.bjc.6602203.
  43. Zhang X, de Oliveira Andrade F, Zhang H, et al. Maternal obesity increases offspring’s mammary cancer recurrence and impairs tumor immune response. Endocr Relat Cancer 2020; 27: 469–482. doi: 10.1530/ERC-20-0065.
  44. Poissonnet CM, Burdi AR, Garn SM. The chronology of adipose tissue appearance and distribution in the human fetus. Early Hum Dev 1984; 10: 1–11. doi: 10.1016/0378-3782(84)90106-3.
  45. Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 2013; 19: 1338–1344. doi: 10.1038/nm.3324.
  46. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783–809. doi: 10.1152/physrev.1998.78.3.783.
  47. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147–1156. doi: 10.1016/0092-8674(94)90006-X.
  48. Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011; 12: 722–734. doi: 10.1038/nrm3198.
  49. Gesta S, Blüher M, Yamamoto Y, et al. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci USA 2006; 103: 6676–6681. doi: 10.1073/pnas.0601752103.
  50. Yamamoto Y, Gesta S, Lee KY, et al. Adipose depots possess unique developmental gene signatures. Obesity (Silver Spring) 2010; 18: 872–878. doi: 10.1038/oby.2009.512.
  51. Lazarescu O, Ziv-Agam M, Haim Y, et al. Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns. Nat Genet 2025; 57: 413–426. doi: 10.1038/s41588-024-02048-3.
  52. Poret JM, Souza-Smith F, Marcell SJ, et al. High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond) 2018; 42: 535–541. doi: 10.1038/ijo.2017.280.
  53. Bilal M, Nawaz A, Kado T, et al. Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet. Mol Metab 2021; 54: 101328. doi: 10.1016/j.molmet.2021.101328.
  54. Ghaben AL, Scherer PE. Adipogenesis and metabolic health. Nat Rev Mol Cell Biol 2019; 20: 242–258. doi: 10.1038/s41580-018-0093-z.
  55. Landgraf K, Rockstroh D, Wagner IV, et al. Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Diabetes 2015; 64: 1249–1261. doi: 10.2337/db14-0744.
  56. Mujkić R, Šnajder Mujkić D, et al. Early childhood fat tissue changes – adipocyte morphometry, collagen deposition, and expression of CD163+ cells in subcutaneous and visceral adipose tissue of male children. Int J Environ Res Public Health 2021; 18: 3627. doi: 10.3390/ijerph18073627.
  57. Halberg N, Khan T, Trujillo ME, et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009; 29: 4467–4483. doi: 10.1128/MCB.00192-09.
  58. Fujisaka S, Usui I, Ikutani M, et al. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1a-dependent and HIF-1a-independent manner in obese mice. Diabetologia 2013; 56: 1403–1412. doi: 10.1007/s00125-013-2885-1.
  59. Zhou N, Zheng W, Peng L, et al. HIF1a elevations at tissue and serum levels and their association with metabolic disorders in children with obesity. J Clin Endocrinol Metab 2024; 109: 1241–1249. doi: 10.1210/clinem/dgad710.
  60. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425–432. doi: 10.1038/372425a0.
  61. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 1155–1161. doi: 10.1038/nm1195-1155.
  62. Wang B, Wood IS, Trayhurn P. Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol 2008; 198: 127–134. doi: 10.1677/JOE-08-0156.
  63. Pilcová R, Sulcová J, Hill M, et al. Leptin levels in obese children: effects of gender, weight reduction and androgens. Physiol Res 2023; 52: 53–60.
  64. Antunes H, Santos C, Carvalho S. Serum leptin levels in overweight children and adolescents. Br J Nutr 2009; 101: 1262–1266. doi: 10.1017/S0007114508055682.
  65. Aygun AD, Gungor S, Ustundag B, et al. Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children. Mediators Inflamm 2005; 2005: 180–183. doi: 10.1155/MI.2005.180.
  66. Vales-Villamarín C, de Dios O, Pérez-Nadador I, et al. Leptin concentrations determine the association between high-sensitivity C-reactive protein levels and body mass index in prepubertal children. Nutrients 2023; 15: 2388. doi: 10.3390/nu15102388.
  67. Zareifar S, Shorafa S, Haghpanah S, et al. Association of serum leptin level with obesity in children with acute lymphoblastic leukemia. Iran J Pediatr Hematol Oncol 2015; 5: 116–124.
  68. Egnell C, Ranta S, Banerjee J, et al. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. Eur J Haematol 2020; 105: 797–807. doi: 10.1111/ejh.13517.
  69. Núñez-Enríquez JC, Gil-Hernández AE, Jiménez-Hernández E, et al. Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study. BMC Cancer 2019; 19: 708. doi: 10.1186/s12885-019-5878-8.
  70. Orgel E, Tucci J, Alhushki W, et al. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood 2014; 124: 3932–3938. doi: 10.1182/blood-2014-08-595389.
  71. Baumann H, Morella KK, White DW, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A 1996; 93: 8374–8378. doi: 10.1073/pnas.93.16.8374.
  72. Brabant G, Horn R, von zur Mühlen A, et al. Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia 2000; 43: 438–442. doi: 10.1007/s001250051326.
  73. Friedman JM. Leptin and the endocrine control of energy balance. Nat Metab 2019; 1: 754–764. doi: 10.1038/s42255-019-0095-y.
  74. Pérez-Pérez A, Sánchez-Jiménez F, Vilariño-García T, Sánchez-Margalet V. Role of leptin in inflammation and vice versa. Int J Mol Sci 2020; 21: 5887. doi: 10.3390/ijms21165887.
  75. Abella V, Scotece M, Conde J, et al. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol 2017; 13: 100–109. doi: 10.1038/nrrheum.2016.209.
  76. Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000; 275: 14563–14572. doi: 10.1074/jbc.275.19.14563.
  77. Kiernan K, MacIver NJ. The role of the adipokine leptin in immune cell function in health and disease. Front Immunol 2021; 11: 622468. doi: 10.3389/fimmu.2020.622468.
  78. Liu J, Lai F, Hou Y, Zheng R. Leptin signaling and leptin resistance. Med Rev 2021; 2: 363–384. doi: 10.1515/mr-2022-0017.
  79. Lin TC, Hsiao M. Leptin and cancer: updated functional roles in carcinogenesis, therapeutic niches, and developments. Int J Mol Sci 2021; 22: 2870. doi: 10.3390/ijms22062870.
  80. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87–91. doi: 10.1126/science.7678183.
  81. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2023; 112: 1796–1808. doi: 10.1172/JCI19246.
  82. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175–184. doi: 10.1172/JCI29881.
  83. Landgraf K, Rockstroh D, Wagner IV, et al. Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Diabetes 2015; 64: 1249–1261. doi: 10.2337/db14-0744.
  84. McLaughlin T, Ackerman SE, Shen L, Engleman E. Role of innate and adaptive immunity in obesity-associated metabolic disease. J Clin Invest 2017; 127: 5–13. doi: 10.1172/JCI88876.
  85. Wang Q, Wang Y, Xu D. The roles of T cells in obese adipose tissue inflammation. Adipocyte 2021; 10: 435–445. doi: 10.1080/21623945.2021.1965314.
  86. Bapat SP, Liang Y, Zheng Y. Characterization of immune cells from adipose tissue. Curr Protoc Immunol 2019; 126: e86. doi: 10.1002/cpim.86.
  87. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15: 914–920. doi: 10.1038/nm.1964.
  88. Kintscher U, Hartge M, Hess K, et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008; 28: 1304–1310. doi: 10.1161/ATVBAHA.108.165100.
  89. Kiran S, Kumar V, Murphy EA, et al. High fat diet-induced CD8+ T cells in adipose tissue mediate macrophages to sustain low-grade chronic inflammation. Front Immunol 2021; 12: 680944. doi: 10.3389/fimmu.2021.680944.
  90. Liao X, Zeng Q, Xie L, et al. Adipose stem cells control obesity-induced T cell infiltration into adipose tissue. Cell Rep 2024; 43: 113963. doi: 10.1016/j.celrep.2024.113963.
  91. Tourniaire F, Romier-Crouzet B, Lee JH, et al. Chemokine expression in inflamed adipose tissue is mainly mediated by NF-kB. PLoS One 2013; 8: e66515. doi: 10.1371/journal.pone.0066515.
  92. Mahlakõiv T, Flamar AL, Johnston LK, et al. Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33. Sci Immunol 2019; 4: eaax0416. doi: 10.1126/sciimmunol.aax0416.
  93. Rausch ME, Weisberg S, Vardhana P, et al. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008; 32: 451–463. doi: 10.1038/sj.ijo.0803744.
  94. Sharma M, Boytard L, Hadi T, et al. Enhanced glycolysis and HIF-1a activation in adipose tissue macrophages sustains local and systemic interleukin-1b production in obesity. Sci Rep 2020; 10: 5555. doi: 10.1038/s41598-020-62272-9.
  95. Winer S, Chan Y, Paltser G, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009; 15: 921–929. doi: 10.1038/nm.2001.
  96. Deng T, Lyon CJ, Minze LJ, et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab 2013; 17: 411–422. doi: 10.1016/j.cmet.2013.02.009.
  97. Hildreth AD, Ma F, Wong YY, et al. Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity. Nat Immunol 2021; 22: 639–653. doi: 10.1038/s41590-021-00922-4.
  98. Emont MP, Jacobs C, Essene AL, et al. A single-cell atlas of human and mouse white adipose tissue. Nature 2022; 603: 926–933. doi: 10.1038/s41586-022-04518-2.
  99. Dieme A, André S, Lapillonne H, et al. Characterization of lymphocyte profiles in children with syndromic obesity. Arch Pediatr 2023; 30: 212–218. doi: 10.1016/j.arcped.2023.02.009.
  100. Medeiros NI, Mattos RT, Menezes CA, et al. IL-10 and TGF-b unbalanced levels in neutrophils contribute to increase inflammatory cytokine expression in childhood obesity. Eur J Nutr 2018; 57: 2421–2430. doi: 10.1007/s00394-017-1515-y.
  101. Artemniak-Wojtowicz D, Rumińska M, Stelmaszczyk-Emmel A, et al. Inflammatory Th17 cells are correlated with insulin resistance and erythrocyte parameters in overweight and obese children. Front Endocrinol (Lausanne) 2024; 15: 1456203. doi: 10.3389/fendo.2024.1456203.
  102. Tobin LM, Mavinkurve M, Carolan E, et al. NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight 2017; 2: e94939. doi: 10.1172/jci.insight.94939.
  103. Bhaskaran K, Douglas I, Forbes H, et al. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014; 384: 755–765. doi: 10.1016/S0140-6736(14)60892-8.
  104. Wang KW, Souza RJ, Fleming A, et al. Adiposity in childhood brain tumors: a report from the Canadian Study of Determinants of Endometabolic Health in Children (CanDECIDE Study). Sci Rep 2017; 7: 45078. doi: 10.1038/srep45078.
  105. Sachdeva P, Ghosh S, Ghosh S, et al. Childhood obesity: a potential key factor in the development of glioblastoma multiforme. Life (Basel) 2022; 12: 1673. doi: 10.3390/life12101673.
  106. Ara T, Song L, Shimada H, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res 2009; 69: 329–337. doi: 10.1158/0008-5472.CAN-08-0613.
  107. Orgel E, Genkinger JM, Aggarwal D, et al. Association of body mass index and survival in pediatric leukemia: a meta-analysis. Am J Clin Nutr 2016; 103: 808–817. doi: 10.3945/ajcn.115.124586.
  108. Pramanik R, Sheng X, Ichihara B, et al. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk Res 2013; 37: 503–509. doi: 10.1016/j.leukres.2012.12.013.
  109. Tucci J, Chen T, Margulis K, et al. Adipocytes provide fatty acids to acute lymphoblastic leukemia cells. Front Oncol 2021; 11: 665763. doi: 10.3389/fonc.2021.665763.
  110. Pasupuleti SK, Ramdas B, Burns SS, et al. Obesity-induced inflammation exacerbates clonal hematopoiesis. J Clin Invest 2023; 133: e163968. doi: 10.1172/JCI163968.
  111. Stone TW, McPherson M, Gail Darlington L. Obesity and cancer: existing and new hypotheses for a causal connection. EBioMedicine 2018; 30: 14–28. doi: 10.1016/j.ebiom.2018.02.022.
  112. Huang T, Song J, Gao J, et al. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. Nat Commun 2022; 13: 3489. doi: 10.1038/s41467-022-31126-5.
  113. Folgiero V, Goffredo BM, Filippini P, et al. Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. Oncotarget 2014; 5: 2052–2064. doi: 10.18632/oncotarget.1504.
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